DNA ligase C; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family.

Probable Fmu protein (sun protein); May act as RNA methyltransferase.

Multifunctional non-homologous end joining DNA repair protein LigD; With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs DNA double-strand breaks (DSB) with reduced fidelity. Recognizes, processes and reseals DSBs, including repairs on incompatible DSB which require 3'-resection, gap filling and ligation. Anneals the 3' overhanging strands from opposing breaks to form a gapped intermediate, which then can be extended in trans by using the termini as primers for extension of the annealed break. Binds to the recessed 5'-phosphate moiety of the downstream DNA stra [...]

Probable holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

Probable DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.

Probable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS); Rv0041, (MTCY21D4.04), len: 969 aa. Probable leucyl-tRNA synthetase, similar to many. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family.

RecBCD enzyme subunit RecB; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...]

Rv3015c, (MTV012.29c), len: 337 aa. Conserved hypothetical protein, equivalent to Q9CBR6|ML1706 hypothetical protein from Mycobacterium leprae (337 aa),FASTA scores: opt: 1703, E(): 3.1e-92, (78.05% identity in 337 aa overlap); and (but longer 47 aa) O33101|MLCB637.09 hypothetical 30.0 KDA protein from Mycobacterium leprae (290 aa), FASTA scores: opt: 1564, E(): 2.4e-78, (78.6% identity in 290 aa overlap). Also similar to Q9Z586|SC8D9.05 hypothetical 35.0 KDA protein from Streptomyces coelicolor (331 aa), FASTA scores: opt: 774,E(): 4.7e-38, (43.4% identity in 334 aa overlap); and show [...]

Probable ATP-dependent DNA helicase II UvrD1; DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. A minimal tail of 18 nt is required for activity. Also highly efficient on nicked DNA. Involved in the post-incision events of nucleotide excision repair, as well as in nitrosative and oxidative stress response and possibly in persistence in the host. Inhibits RecA-mediated DNA strand exchange; this does not require ATPase activity. When combined with UvrA greatly inhibits RecA- mediated DNA strand exchange; Belongs to the helicase family. UvrD sub [...]