STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sseC1Rv3118, (MTCY164.28, O05794), len: 100 aa. SseC1,conserved hypothetical protein, equivalent to Q9CBC7|ML2199 hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 545, E(): 3.1e-30, (84.0% identity in 10 aa overlap). Also similar to hypothetical proteins e.g. Q50035 from Saccharopolyspora erythraea (Streptomyces erythraeus) (101 aa), FASTA scores: opt: 345, E(): 9.7e-17,(57.15% identity in 98 aa overlap); and Q9K4H3|SCD66.02 from Streptomyces coelicolor (95 aa), FASTA scores: opt: 249, E(): 2.8e-10, (48.5% identity in 99 aa overlap). Some weak similarity with Q9ZB8 [...] (100 aa)    
Predicted Functional Partners:
cysA3
Rv3117, (MTCY164.27, MT3199, O05793), len: 277 aa. Probable cysA3 (alternate gene name: sseC3), thiosulfate sulfurtransferase (see Wooff et al., 2002), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE putative sulfurtransferase thiosulfate from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1442, E(): 1.7e-84, (75.55% identity in 274 aa overlap); Q9RXT9DR0217|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: [...]
 
  
 0.972
moaE1
Molybdopterin synthase catalytic subunit 1; Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity); Belongs to the MoaE family.
  
  
 0.943
cysA2
Putative thiosulfate sulfurtransferase; May be a sulfotransferase involved in the formation of thiosulfate.
 
  
 0.942
cyp141
Rv3121, (MTCY164.31), len: 400 aa. Probable cyp141,cytochrome P-450 integral membrane protein, similar to other cytochrome P450-dependent oxidases e.g. Q9X5P9|CYP107N1 from Streptomyces lavendulae (410 aa),FASTA scores: opt: 825, E(): 3.1e-42, (33.35% identity in 393 aa overlap); Q59819|OLEP|CYP107D1 from Streptomyces antibioticus (407 aa), FASTA scores: opt: 812, E(): 1.9e-41, (34.85% identity in 396 aa overlap); O32460|CYP107M1 from Actinomadura hibisca (411 aa), FASTA scores: opt: 713, E(): 1.6e-35, (31.05% identity in 396 aa overlap); P55544|CPXP_RHISN|CYP112A|Y4LD from Rhizobium s [...]
  
  
 0.871
Rv2844
Rv2844, (MTCY24A1.13c), len: 162 aa. Conserved ala-rich protein, equivalent to Q9Z5J4|ML1561|MLCB596.09c hypothetical 17.5 KDA protein from Mycobacterium leprae (165 aa), FASTA scores: opt: 771, E(): 4.9e-46, (71.5% identity in 165 aa overlap). Also similar to Q9KYR4|SC5H4.25c hypothetical 16.8 KDA protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 242,E(): 1.6e-09, (38.9% identity in 144 aa overlap).
  
    0.727
Rv3120
Rv3120, (MTCY164.30), len: 200 aa. Conserved hypothetical protein, with weak similarity to several hypothetical proteins and many N-methyl transferases e.g. Q9X9V1|ORF8 putative methyltransferase from Streptomyces coelicolor A3(2) (208 aa), FASTA scores: opt: 177, E(): 0.00011, (34.6% identity in 130 aa overlap); Q9XA90|SCF43A.25c putative methyltransferase from Streptomyces coelicolor (215 aa), FASTA scores: opt: 147,E(): 0.011, (31.3% identity in 166 aa overlap); BAB52127|MLL5735 probable methyltransferase from Rhizobium loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 133,E(): [...]
  
    0.722
Rv2468c
Conserved protein; Rv2468c, (MTV008.24c), len: 167 aa. Conserved protein, highly similar to Mycobacterium leprae hypothetical proteins Q9CC58|ML1255 (163 aa), FASTA scores: opt: 859, E(): 1.6e-49, (81.2% identity in 165 aa overlap) and Q9X7B5|MLCB1610.16 (169 aa), FASTA scores: opt: 859,E(): 1.6e-49, (81.2% identity in 165 aa overlap). Also weak similarity with Q9X8D7|SCE39.14c putative GntR-family regulator from Streptomyces coelicolor (243 aa), FASTA scores: opt: 116, E(): 1.3, (30.1% identity in 156 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marm [...]
  
    0.687
moeB2
Sulfur-carrier protein adenylyltransferase/sulfurtransferase; Rv3116, (MTCY164.26), len: 389 aa. Probable moeB2,molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 protein probably involved in molybdopterin biosynthesis from Mycobacterium leprae (395 aa), FASTA scores: opt: 1433, E(): 8e-80, (57.8% identity in 384 aa overlap). Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 putative sulfurylase from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1562, E(): 1.1e-87, (58.15% identity in 380 aa overlap); Q9XC37|PDTORFF MOEB-like p [...]
  
    0.682
Rv2365c
Rv2365c, (MTCY27.15), len: 113 aa. Conserved hypothetical protein, highly similar to Q49767|ML0630|B1937_F3_101|CAC30138 Hypothetical protein from Mycobacterium leprae (108 aa), FASTA scores: opt: 426,E(): 1.4e-18, (67.9% identity in 106 aa overlap). Also highly similar to Q9RDF3|SCC77.05 from Streptomyces coelicolor (132 aa), FASTA scores: opt: 254, E(): 1.9e-18,(53.1% identity in 96 aa overlap). Equivalent to AAK46728 from Mycobacterium tuberculosis strain CDC1551 (93 aa) but longer 20 aa.
  
    0.638
pup
Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Among the identified substrates are the FabD, PanB and Mpa proteins. Belongs to the prokaryotic ubiquitin-like protein family.
  
  
 0.630
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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