birA protein (Mycobacterium tuberculosis H37Rv) - STRING interaction network
"birA" - Rv3279c, in Mycobacterium tuberculosis H37Rv
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
birARv3279c, (MTCY71.19c), len- 266 aa. Possible birA,bifunctional protein- biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase, equivalent to Q9CCL3|BIRA|ML0732 biotin APO-protein ligase from Mycobacterium leprae (274 aa), FASTA scores- opt- 1189,E()- 2.3e-66, (71.2% identity in 271 aa overlap). But as it lacks a BirA h-t-h domain at N-terminus, may simply be biotin apo-protein ligase. Also similar to others e.g. Q9CNX6|BIRA|PM0296 from Pasteurella multocida (312 aa),FASTA scores- opt- 347, E()- 2.7e-14, (32.95% identity in 270 aa overlap); Q9HWC0|BIRA|PA4280 from Pseu [...] (266 aa)    
Predicted Functional Partners:
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (349 aa)
Rv1442, (MTCY493.12c), len- 766 aa. Probable bisC,Biotin sulfoxide reductase, similar to BISC_ECOLI|P20099 biotin sulfoxide reductase from Escherichia coli (739 aa),FASTA scores- opt- 1271, E()-0, (40.2% identity in 744 aa overlap); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family (766 aa)
Rv3285, (MTCY71.25), len- 600 aa. Probable accA3,bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (see citations below) equivalent to P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129 acetyl-/propionyl-coenzyme A carboxylase alpha chain from Mycobacterium leprae (598 aa), FASTA scores- opt- 3510,E()- 1.1e-196, (89.3% identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC acyl coenzyme A carboxylase from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa), FASTA scores- opt- 2776,E()- 5.6e-154, (71.95% identity in 592 aa overlap); [...] (600 aa)
Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate; Belongs to the LipB family (230 aa)
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (134 aa)
Rv3280, (MTCY71.20, pccB), len- 548 aa. Probable accD5, propionyl-CoA carboxylase beta chain 5, equivalent to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 probable propionyl-CoA carboxylase beta chain 5 from Mycobacterium leprae (549 aa), FASTA scores- opt- 3241, E()- 4e-192,(88.7% identity in 549 aa overlap). Also similar to many e.g. O87201|DTSR2 DTSR2 protein involved in glutamate production from Corynebacterium glutamicum (Brevibacterium flavum) (537 aa), FASTA scores- opt- 2604, E()- 6.9e-153,(74.1% identity in 529 aa overlap) (see Kimura et al.,1996); P53003|PCCB_SACER from Saccha [...] (548 aa)
acetyl/propionyl-CoA carboxylase subuit alpha; Rv0973c, (MTV044.01c, MTCY10D7.01), len- 667 aa. Probable accA2 (alternate gene name- bccA),acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [includes- biotin carboxylase ; biotin carboxyl carrier protein (BCCP)], highly similar to others e.g. CAB95892.1|AL359988 putative acetyl/propionyl CoA carboxylase alpha subunit from Streptomyces coelicolor (614 aa); NP_250702.1|NC_002516 probable acyl-CoA carboxylase alpha chain from Pseudomonas aeruginosa (655 aa); NP_420971.1|NC_002696 acetyl/propionyl-CoA carboxylase alpha subunit from Ca [...] (667 aa)
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. In vitro, can also use ammonia with comparable specific activity (679 aa)
Rv3278c, (MTCY71.18c), len- 172 aa. Probable conserved transmembrane protein, equivalent to Q9CCL2|ML0733 putative membrane protein from Mycobacterium leprae (172 aa), FASTA scores- opt- 1024, E()- 6e-61,(83.15% identity in 172 aa overlap); and Q49672|B1308_F2_67 hypothetical protein from Mycobacterium leprae (181 aa),FASTA scores- opt- 1024, E()- 6.3e-61, (83.15% identity in 172 aa overlap) (this is certainly the same putative protein but with N-terminus longer). Also some similarity to other hypothetical proteins (generally membrane proteins) e.g. O26822|MTH726 hypothetical protein f [...] (172 aa)
Rv2524c, (MTCY159.32, MTV009.09c), len- 3069 aa. Probable fas, Fatty Acid Synthase, equivalent to Q9X7E2|fas|ML1191 putative type I fatty acid synthase from Mycobacterium leprae (3076 aa), FASTA scores- opt- 17484,E()- 0, (85.8% identity in 3081 aa overlap). Also similar to others e.g. Q04846|fas|Q59497 from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (3104 aa), FASTA scores- opt- 3981, E()- 5.5e-203, (49.8% identity in 3099 aa overlap); Q48926|fas from Mycobacterium bovis (2796 aa),FASTA scores- opt- 2098, E()- 3.9e-103, (59.7% identity in 2862 aa overlap) (see Fernande [...] (3069 aa)
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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