node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3386 | Rv3387 | Rv3386 | Rv3387 | Possible transposase; Rv3386, (MTV004.44), len: 234 aa. Possible transposase, showing very weak similarity to several is element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap). | Possible transposase; Rv3387, (MTV004.45), len: 225 aa. Possible transposase, showing very weak similarity to other is element proteins, and similar to various hypothetical proteins. | 0.985 |
Rv3386 | vapB46 | Rv3386 | Rv3385c | Possible transposase; Rv3386, (MTV004.44), len: 234 aa. Possible transposase, showing very weak similarity to several is element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap). | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | 0.544 |
Rv3386 | vapC46 | Rv3386 | Rv3384c | Possible transposase; Rv3386, (MTV004.44), len: 234 aa. Possible transposase, showing very weak similarity to several is element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap). | Possible toxin VapC46. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB46.; Belongs to the PINc/VapC protein family. | 0.524 |
Rv3387 | Rv3386 | Rv3387 | Rv3386 | Possible transposase; Rv3387, (MTV004.45), len: 225 aa. Possible transposase, showing very weak similarity to other is element proteins, and similar to various hypothetical proteins. | Possible transposase; Rv3386, (MTV004.44), len: 234 aa. Possible transposase, showing very weak similarity to several is element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap). | 0.985 |
Rv3387 | vapB46 | Rv3387 | Rv3385c | Possible transposase; Rv3387, (MTV004.45), len: 225 aa. Possible transposase, showing very weak similarity to other is element proteins, and similar to various hypothetical proteins. | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | 0.542 |
Rv3387 | vapC46 | Rv3387 | Rv3384c | Possible transposase; Rv3387, (MTV004.45), len: 225 aa. Possible transposase, showing very weak similarity to other is element proteins, and similar to various hypothetical proteins. | Possible toxin VapC46. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB46.; Belongs to the PINc/VapC protein family. | 0.524 |
vapB46 | Rv3386 | Rv3385c | Rv3386 | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible transposase; Rv3386, (MTV004.44), len: 234 aa. Possible transposase, showing very weak similarity to several is element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap). | 0.544 |
vapB46 | Rv3387 | Rv3385c | Rv3387 | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible transposase; Rv3387, (MTV004.45), len: 225 aa. Possible transposase, showing very weak similarity to other is element proteins, and similar to various hypothetical proteins. | 0.542 |
vapB46 | vapB47 | Rv3385c | Rv3407 | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible antitoxin VapB47; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC47. | 0.612 |
vapB46 | vapB5 | Rv3385c | Rv0626 | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5. | 0.545 |
vapB46 | vapC35 | Rv3385c | Rv1962c | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible toxin VapC35. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB35.; Belongs to the PINc/VapC protein family. | 0.766 |
vapB46 | vapC4 | Rv3385c | Rv0595c | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. | 0.443 |
vapB46 | vapC46 | Rv3385c | Rv3384c | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible toxin VapC46. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB46.; Belongs to the PINc/VapC protein family. | 0.959 |
vapB46 | vapC47 | Rv3385c | Rv3408 | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible toxin VapC47. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits translation and colony formation. Its toxic effect on colony formation is neutralized by coexpression with cognate antitoxin VapB47; the effect on translation has not been tested but is probably neutralized also.; Belongs to the PINc/VapC protein family. | 0.786 |
vapB46 | vapC5 | Rv3385c | Rv0627 | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible toxin VapC5; Probable toxic component of a type II toxin-antitoxin (TA) system. The cognate antitoxin is VapB5. Has limited RNase activity on substrates; activity is seen with a VapC5-VapB5 complex. | 0.498 |
vapB46 | vapC8 | Rv3385c | Rv0665 | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | Possible toxin VapC8; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB8 (By similarity); Belongs to the PINc/VapC protein family. | 0.502 |
vapB47 | vapB46 | Rv3407 | Rv3385c | Possible antitoxin VapB47; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC47. | Possible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46. | 0.612 |
vapB47 | vapB5 | Rv3407 | Rv0626 | Possible antitoxin VapB47; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC47. | Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5. | 0.402 |
vapB47 | vapC35 | Rv3407 | Rv1962c | Possible antitoxin VapB47; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC47. | Possible toxin VapC35. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB35.; Belongs to the PINc/VapC protein family. | 0.712 |
vapB47 | vapC4 | Rv3407 | Rv0595c | Possible antitoxin VapB47; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC47. | Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. | 0.503 |