node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1086 | grcC1 | Rv1086 | Rv0562 | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | 0.904 |
Rv1086 | grcC2 | Rv1086 | Rv0989c | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase); Rv0989c, (MTCI237.03c), len: 325 aa. Probable grcC2,polyprenyl diphosphate synthetase, highly similar to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to heptaprenyl diphosphate synthase component II (menaquinone biosynthesis) from Listeria innocua (321 aa); NP_371994.1|NC_002758 heptaprenyl diphosphate syntase component II from Staphylococcus aureus su [...] | 0.749 |
Rv1086 | idi | Rv1086 | Rv1745c | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.939 |
Rv1086 | idsA1 | Rv1086 | Rv3398c | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | (2E,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis. Belongs to the FPP/GGPP synthase family. | 0.980 |
Rv1086 | idsA2 | Rv1086 | Rv2173 | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Rv2173, (MTV021.06), len: 352 aa. Probable idsA2,geranylgeranyl pyrophosphate synthase, similar to many e.g. Q54193 geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa). Contains PS00723 and PS00444Polyprenyl synthetases signature 1 and 2. FASTA scores: sptr|Q54193|Q54193 geranylgeranyl pyrophosphate synthase (425 aa) opt: 744, E(): 0; 39.2% identity in 352 aa overlap. | 0.986 |
Rv1086 | idsB | Rv1086 | Rv3383c | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Rv3383c, (MTV004.41c), len: 350 aa. Possible idsB,polyprenyl transferase (polyprenyl diphosphate synthase), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR geranyl transferase from Streptomyces coelicolor (386 aa), FASTA scores: opt: 908,E(): 3.7e-50, (48.8/% identity in 334 aa overlap); Q9KWG0|GGDPS geranyl geranyl diphosphate synthase from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity in 347 aa overlap); Q9X7V8|SC6A5.12 putative polyprenyl synthetase from Streptomyces coelicolor (3 [...] | 0.978 |
Rv1086 | lytB1 | Rv1086 | Rv3382c | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Probable LYTB-related protein LytB1; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Has a reduced activity compared with LytB2. Is unable to functionally complement the loss of lytB2 in M.tuberculosis. Belongs to the IspH family. | 0.907 |
Rv1086 | lytB2 | Rv1086 | Rv1110 | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Probable LYTB-related protein LytB2; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Has a higher activity compared with LytB2. Is essential for M.tuberculosis growth in vitro. | 0.909 |
Rv1086 | phyA | Rv1086 | Rv3397c | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.680 |
Rv1086 | uppS | Rv1086 | Rv2361c | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and (2E,6E,10E)-geranylgeranyl diphosphate (EEE-GGPP) are synthesized. M.tuberculosis does not synthesize (2E,6E,10Z)- geranylgeranyl diphosphate (EEZ-GGPP) and heptapreny [...] | 0.940 |
grcC1 | Rv1086 | Rv0562 | Rv1086 | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | (2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | 0.904 |
grcC1 | grcC2 | Rv0562 | Rv0989c | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase); Rv0989c, (MTCI237.03c), len: 325 aa. Probable grcC2,polyprenyl diphosphate synthetase, highly similar to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to heptaprenyl diphosphate synthase component II (menaquinone biosynthesis) from Listeria innocua (321 aa); NP_371994.1|NC_002758 heptaprenyl diphosphate syntase component II from Staphylococcus aureus su [...] | 0.906 |
grcC1 | idi | Rv0562 | Rv1745c | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.784 |
grcC1 | idsA1 | Rv0562 | Rv3398c | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | (2E,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis. Belongs to the FPP/GGPP synthase family. | 0.948 |
grcC1 | idsA2 | Rv0562 | Rv2173 | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | Rv2173, (MTV021.06), len: 352 aa. Probable idsA2,geranylgeranyl pyrophosphate synthase, similar to many e.g. Q54193 geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa). Contains PS00723 and PS00444Polyprenyl synthetases signature 1 and 2. FASTA scores: sptr|Q54193|Q54193 geranylgeranyl pyrophosphate synthase (425 aa) opt: 744, E(): 0; 39.2% identity in 352 aa overlap. | 0.946 |
grcC1 | idsB | Rv0562 | Rv3383c | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | Rv3383c, (MTV004.41c), len: 350 aa. Possible idsB,polyprenyl transferase (polyprenyl diphosphate synthase), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR geranyl transferase from Streptomyces coelicolor (386 aa), FASTA scores: opt: 908,E(): 3.7e-50, (48.8/% identity in 334 aa overlap); Q9KWG0|GGDPS geranyl geranyl diphosphate synthase from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity in 347 aa overlap); Q9X7V8|SC6A5.12 putative polyprenyl synthetase from Streptomyces coelicolor (3 [...] | 0.941 |
grcC1 | lytB1 | Rv0562 | Rv3382c | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | Probable LYTB-related protein LytB1; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Has a reduced activity compared with LytB2. Is unable to functionally complement the loss of lytB2 in M.tuberculosis. Belongs to the IspH family. | 0.682 |
grcC1 | lytB2 | Rv0562 | Rv1110 | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | Probable LYTB-related protein LytB2; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Has a higher activity compared with LytB2. Is essential for M.tuberculosis growth in vitro. | 0.582 |
grcC1 | phyA | Rv0562 | Rv3397c | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.903 |
grcC1 | uppS | Rv0562 | Rv2361c | Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa), FASTA scores: opt: 599, E(): 4e-31,(33.2% identity in 307 aa overlap); etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c p [...] | Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and (2E,6E,10E)-geranylgeranyl diphosphate (EEE-GGPP) are synthesized. M.tuberculosis does not synthesize (2E,6E,10Z)- geranylgeranyl diphosphate (EEZ-GGPP) and heptapreny [...] | 0.936 |