node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
csm3 | lipF | Rv2821c | Rv3487c | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate t [...] | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | 0.593 |
fadD21 | lipF | Rv1185c | Rv3487c | Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1185c, (MTV005.21c), len: 578 aa. Probable fadD21,fatty-acid-AMP synthetase, highly similar to several from Mycobacteria e.g. NP_301895.1|NC_002677 possible acyl-CoA synthase from Mycobacterium leprae (579 aa); P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2388, E(): 0, (61.8% identity in 579 aa overlap); etc. Seems to belong to the ATP-dependent AMP-binding enzyme family. Nucleotide position 1327402 in the genome sequence has been corrected, T:C result [...] | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | 0.702 |
fadD21 | pks2 | Rv1185c | Rv3825c | Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1185c, (MTV005.21c), len: 578 aa. Probable fadD21,fatty-acid-AMP synthetase, highly similar to several from Mycobacteria e.g. NP_301895.1|NC_002677 possible acyl-CoA synthase from Mycobacterium leprae (579 aa); P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2388, E(): 0, (61.8% identity in 579 aa overlap); etc. Seems to belong to the ATP-dependent AMP-binding enzyme family. Nucleotide position 1327402 in the genome sequence has been corrected, T:C result [...] | Polyketide synthase Pks2; Catalyzes the synthesis of the hepta- and octamethyl phthioceranic acids and/or hydroxyphthioceranic acids that are the major acyl constituents of sulfolipids. | 0.888 |
fadD21 | pks4 | Rv1185c | Rv1181 | Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1185c, (MTV005.21c), len: 578 aa. Probable fadD21,fatty-acid-AMP synthetase, highly similar to several from Mycobacteria e.g. NP_301895.1|NC_002677 possible acyl-CoA synthase from Mycobacterium leprae (579 aa); P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2388, E(): 0, (61.8% identity in 579 aa overlap); etc. Seems to belong to the ATP-dependent AMP-binding enzyme family. Nucleotide position 1327402 in the genome sequence has been corrected, T:C result [...] | Probable polyketide beta-ketoacyl synthase Pks4; Polyketide synthase involved in the biosynthesis of methyl- branched fatty acids such as mycolipanoic, mycolipenic (phthienoic) and mycolipodienoic acids required for the synthesis of a major class of polyacylated trehaloses. Catalyzes the elongation of CoA esters of long-chain fatty acids by incorporation of three methylmalonyl (but not malonyl) residues, to form trimethyl-branched fatty-acids. | 0.879 |
lipC | lipF | Rv0220 | Rv3487c | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | 0.796 |
lipC | lipV | Rv0220 | Rv3203 | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Possible lipase LipV; Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP-octanoate (82%), pNP- decanoate (90%), and pNP-laurate (74%). Is probably involved in lipid catabolism. Is active at low pH, and might play some important role in mycobacterial biology in macrophages where the bacteria encounters acidic stress. | 0.459 |
lipC | lipY | Rv0220 | Rv3097c | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Triacylglycerol lipase; Responsible for the utilization of stored long-chain triacylglycerol (TG) during dormancy and reactivation stage of the infection cycle. Catalyzes the hydrolysis of long-chain triacylglycerol with high specific activity; In the C-terminal section; belongs to the 'GDXG' lipolytic enzyme family. | 0.803 |
lipC | lipZ | Rv0220 | Rv1834 | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). | 0.870 |
lipC | pks2 | Rv0220 | Rv3825c | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Polyketide synthase Pks2; Catalyzes the synthesis of the hepta- and octamethyl phthioceranic acids and/or hydroxyphthioceranic acids that are the major acyl constituents of sulfolipids. | 0.453 |
lipC | pks4 | Rv0220 | Rv1181 | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | Probable polyketide beta-ketoacyl synthase Pks4; Polyketide synthase involved in the biosynthesis of methyl- branched fatty acids such as mycolipanoic, mycolipenic (phthienoic) and mycolipodienoic acids required for the synthesis of a major class of polyacylated trehaloses. Catalyzes the elongation of CoA esters of long-chain fatty acids by incorporation of three methylmalonyl (but not malonyl) residues, to form trimethyl-branched fatty-acids. | 0.425 |
lipF | csm3 | Rv3487c | Rv2821c | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate t [...] | 0.593 |
lipF | fadD21 | Rv3487c | Rv1185c | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1185c, (MTV005.21c), len: 578 aa. Probable fadD21,fatty-acid-AMP synthetase, highly similar to several from Mycobacteria e.g. NP_301895.1|NC_002677 possible acyl-CoA synthase from Mycobacterium leprae (579 aa); P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2388, E(): 0, (61.8% identity in 579 aa overlap); etc. Seems to belong to the ATP-dependent AMP-binding enzyme family. Nucleotide position 1327402 in the genome sequence has been corrected, T:C result [...] | 0.702 |
lipF | lipC | Rv3487c | Rv0220 | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits proinflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immu [...] | 0.796 |
lipF | lipJ | Rv3487c | Rv1900c | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Rv1900c, (MTCY180.18), len: 462 aa. Probable lipJ,lignin peroxidase, with some similarity to esterases,hydrolases and hypothetical Mycobacterium tuberculosis proteins e.g. Q43936 beta-ketoadipate enol-lactone hydrolase from Acinetobacter calcoaceticus (267 aa), FASTA results: opt: 217, E(): 1.7e-07, (29.2% identity in 260 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv2212|Q10400|YM12_MYCTU (378 aa), FASTA results: opt: 216, E(): 6.7e-07, (27.7% identity in 285 aa overlap). | 0.603 |
lipF | lipV | Rv3487c | Rv3203 | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Possible lipase LipV; Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP-octanoate (82%), pNP- decanoate (90%), and pNP-laurate (74%). Is probably involved in lipid catabolism. Is active at low pH, and might play some important role in mycobacterial biology in macrophages where the bacteria encounters acidic stress. | 0.617 |
lipF | lipX | Rv3487c | Rv1169c | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | PE family protein. Possible lipase LipX; Rv1169c, (MTV005.05c), len: 100 aa. Possible lipX,lipase. Member of the Mycobacterium tuberculosis PE family of proteins (see Brennan & Delogu 2002), e.g. O05297|Z93777|MTCI364.07 (99 aa), FASTA scores: opt: 209,E(): 1.6e-15, (37.4% identity in 99 aa overlap). Also simlar to the N-terminus of P77909|U76006 esterase/lipase from Mycobacterium tuberculosis (437 aa), FASTA scores: opt: 193, E(): 4.4e-14, (37.2% identity in 94 aa overlap). Contains a helix-turn-helix motif from aa 88-109 (+2.76 SD). Predicted possible vaccine candidate (See Zvi et al [...] | 0.621 |
lipF | lipY | Rv3487c | Rv3097c | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Triacylglycerol lipase; Responsible for the utilization of stored long-chain triacylglycerol (TG) during dormancy and reactivation stage of the infection cycle. Catalyzes the hydrolysis of long-chain triacylglycerol with high specific activity; In the C-terminal section; belongs to the 'GDXG' lipolytic enzyme family. | 0.856 |
lipF | lipZ | Rv3487c | Rv1834 | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0% identity in 300 aa overlap). | 0.803 |
lipF | pks2 | Rv3487c | Rv3825c | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Polyketide synthase Pks2; Catalyzes the synthesis of the hepta- and octamethyl phthioceranic acids and/or hydroxyphthioceranic acids that are the major acyl constituents of sulfolipids. | 0.629 |
lipF | pks4 | Rv3487c | Rv1181 | Probable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. | Probable polyketide beta-ketoacyl synthase Pks4; Polyketide synthase involved in the biosynthesis of methyl- branched fatty acids such as mycolipanoic, mycolipenic (phthienoic) and mycolipodienoic acids required for the synthesis of a major class of polyacylated trehaloses. Catalyzes the elongation of CoA esters of long-chain fatty acids by incorporation of three methylmalonyl (but not malonyl) residues, to form trimethyl-branched fatty-acids. | 0.607 |