node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3492c | Rv3493c | Rv3492c | Rv3493c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | 0.973 |
Rv3492c | lprN | Rv3492c | Rv3495c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down- regulate the host's immune response. | 0.978 |
Rv3492c | mce4A | Rv3492c | Rv3499c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Mce-family protein Mce4A; Rv3499c, (MTV023.06c), len: 400 aa. Mce4A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar to others e.g. Q9F356|SC8A2.07c putative secreted protein from Streptomyces coelicolor (418 aa), FASTA scores: opt: 619, E(): 7.8e-30, (32.4% identity in 352 aa overlap); Q9S4U5|MCE1 mycobacterial cell entry protein from M [...] | 0.975 |
Rv3492c | mce4B | Rv3492c | Rv3498c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Mce-family protein Mce4B; Rv3498c, (MTV023.05c), len: 350 aa. Mce4B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); and O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to others e.g. Q9CD13|MCE1B|ML2590 putative secreted protein from Mycobacterium leprae (346 aa), FASTA scores: opt: 803,E(): 6.1e-41, (41.05% identity in 346 aa overlap); Q9F357|SC8A2.06c putative secreted protein from Streptomyces coeli [...] | 0.958 |
Rv3492c | mce4C | Rv3492c | Rv3497c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Mce-family protein Mce4C; Rv3497c, (MTV023.04c), len: 357 aa. Mce4C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); and O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to others e.g. Q9F358|SC8A2.05c putative secreted protein from Streptomyces coelicolor (351 aa), FASTA scores: opt: 658,E(): 1.1e-30, (33.95% identity in 318 aa overlap); Q9CD12|MCE1C|ML2591 putative secreted protein from Mycobacterium lep [...] | 0.989 |
Rv3492c | mce4D | Rv3492c | Rv3496c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Mce-family protein Mce4D; Rv3496c, (MTV023.03c), len: 451 aa. Mce4D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to others e.g. Q9CD11|MCE1D|ML2592 putative secreted protein from Mycobacterium leprae (531 aa), FASTA scores: opt: 837,E(): 2.6e-34, (34.55% identity in 446 aa overlap); Q9F359|SC8A2.04c putative secreted protein from Streptomyces coeli [...] | 0.990 |
Rv3492c | mce4F | Rv3492c | Rv3494c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Mce-family protein Mce4F; Rv3494c, (MTV023.01c), len: 564 aa. Mce4F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); and O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to others e.g. Q9CD09|MCE1F|ML2594 putative secreted protein from Mycobacterium leprae (516 aa), FASTA scores: opt: 1040, E(): 3.6e-31, (35.9% identity in 529 aa overlap); Q9F361|SC8A2.02c putative secreted protein from Streptomyces coelicolor [...] | 0.974 |
Rv3492c | yrbE4A | Rv3492c | Rv3501c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Rv3501c, (MTV023.08c), len: 254 aa. YrbE4A,conserved integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa),FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity in 247 aa overlap); P45030|YRBE_ [...] | 0.883 |
Rv3492c | yrbE4B | Rv3492c | Rv3500c | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | Rv3500c, (MTV023.07c), len: 280 aa. YrbE4B,conserved integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa),FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity in 269 aa overlap); P45030|YRBE_ [...] | 0.917 |
Rv3493c | Rv3492c | Rv3493c | Rv3492c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | 0.973 |
Rv3493c | lprN | Rv3493c | Rv3495c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down- regulate the host's immune response. | 0.900 |
Rv3493c | mce4A | Rv3493c | Rv3499c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Mce-family protein Mce4A; Rv3499c, (MTV023.06c), len: 400 aa. Mce4A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar to others e.g. Q9F356|SC8A2.07c putative secreted protein from Streptomyces coelicolor (418 aa), FASTA scores: opt: 619, E(): 7.8e-30, (32.4% identity in 352 aa overlap); Q9S4U5|MCE1 mycobacterial cell entry protein from M [...] | 0.882 |
Rv3493c | mce4B | Rv3493c | Rv3498c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Mce-family protein Mce4B; Rv3498c, (MTV023.05c), len: 350 aa. Mce4B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa); O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); and O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to others e.g. Q9CD13|MCE1B|ML2590 putative secreted protein from Mycobacterium leprae (346 aa), FASTA scores: opt: 803,E(): 6.1e-41, (41.05% identity in 346 aa overlap); Q9F357|SC8A2.06c putative secreted protein from Streptomyces coeli [...] | 0.884 |
Rv3493c | mce4C | Rv3493c | Rv3497c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Mce-family protein Mce4C; Rv3497c, (MTV023.04c), len: 357 aa. Mce4C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); and O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to others e.g. Q9F358|SC8A2.05c putative secreted protein from Streptomyces coelicolor (351 aa), FASTA scores: opt: 658,E(): 1.1e-30, (33.95% identity in 318 aa overlap); Q9CD12|MCE1C|ML2591 putative secreted protein from Mycobacterium lep [...] | 0.901 |
Rv3493c | mce4D | Rv3493c | Rv3496c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Mce-family protein Mce4D; Rv3496c, (MTV023.03c), len: 451 aa. Mce4D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to others e.g. Q9CD11|MCE1D|ML2592 putative secreted protein from Mycobacterium leprae (531 aa), FASTA scores: opt: 837,E(): 2.6e-34, (34.55% identity in 446 aa overlap); Q9F359|SC8A2.04c putative secreted protein from Streptomyces coeli [...] | 0.951 |
Rv3493c | mce4F | Rv3493c | Rv3494c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Mce-family protein Mce4F; Rv3494c, (MTV023.01c), len: 564 aa. Mce4F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa); O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); and O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to others e.g. Q9CD09|MCE1F|ML2594 putative secreted protein from Mycobacterium leprae (516 aa), FASTA scores: opt: 1040, E(): 3.6e-31, (35.9% identity in 529 aa overlap); Q9F361|SC8A2.02c putative secreted protein from Streptomyces coelicolor [...] | 0.905 |
Rv3493c | yrbE4A | Rv3493c | Rv3501c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Rv3501c, (MTV023.08c), len: 254 aa. YrbE4A,conserved integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa),FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity in 247 aa overlap); P45030|YRBE_ [...] | 0.815 |
Rv3493c | yrbE4B | Rv3493c | Rv3500c | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | Rv3500c, (MTV023.07c), len: 280 aa. YrbE4B,conserved integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa),FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity in 269 aa overlap); P45030|YRBE_ [...] | 0.860 |
lprN | Rv3492c | Rv3495c | Rv3492c | Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down- regulate the host's immune response. | Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3% identity in 154 aa overlap); and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al., 2008). | 0.978 |
lprN | Rv3493c | Rv3495c | Rv3493c | Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down- regulate the host's immune response. | Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa), FASTA scores: opt: 163, E(): 0.046, (24.65% identity in 211 aa overlap). | 0.900 |