STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
kshAOxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. KSH is also able to use 4- androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4- BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4 [...] (386 aa)    
Predicted Functional Partners:
kstD
Probable dehydrogenase; Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 3-keto-1,4-diene-steroid from 3-keto- 4-ene-steroid.
 
 
 0.998
kshB
Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. KSH is also able to use 4- androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4- BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4 [...]
 
 
 0.998
Rv3527
Hypothetical protein; Rv3527, (MTCY03C7.29c), len: 149 aa. Hypothetical unknown protein.
 
  
 0.979
hsaC
3,4-DHSA dioxygenase; Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5- 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).
 
  
 0.974
hsaA
Flavin-dependent monooxygenase, oxygenase subunit HsaA; Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta- 1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta- 1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Can use either FADH(2) or FMNH(2) as flavin cosubstrate. Also catalyzes the o-hydroxylation of a range of p-substituted phenols to generate the corresponding catechols.
 
  
 0.959
hsaD
4,9-DHSA hydrolase; Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9- DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5- methyl-6-oxoocta-2,4-dienoic acid (HOPODA). Belongs to the AB hydrolase superfamily. HsaD family.
 
 
 0.945
kstR
Transcriptional regulatory protein KstR (probably TetR-family); Controls the expression of genes used for utilizing diverse lipids as energy sources.
 
  
 0.924
echA20
Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv3550, (MTCY03C7.06c), len: 247 aa. Probable echA20, enoyl-CoA hydratase, similar to others e.g. Q9A7B0|CC1814 from Caulobacter crescentus (275 aa), FASTA scores: opt: 488, E(): 3.5e-24, (36.4% identity in 239 aa overlap); O84978|PHAA from Pseudomonas putida (293 aa),FASTA scores: opt: 383, E(): 2e-17, (33.85% identity in 254 aa overlap); BAB48479|Q98LI4|MLL1009 from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 378, E(): 3.8e-17, (21.45% identity in 231 aa overlap); et [...]
 
  
 0.864
fadE30
Rv3560c, (MTCY06G11.07c), len: 385 aa. Probable fadE30, acyl-CoA dehydrogenase, similar to many e.g. Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 845, E(): 1.6e-47, (39.2% identity in 388 aa overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407 aa), FASTA scores: opt: 734, E(): 2.8e-40, (35.5% identity in 386 aa overlap); Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa), FASTA scores: opt: 656, E(): 3.2e-35,(37.9% identity in 351 aa overlap); etc. Also similar to acyl-CoA dehydrogenases from Mycobacterium tuberculosis e.g. P95280|FADE17|Rv1934c|MTCY09 [...]
 
  
 0.850
kstR2
Transcriptional regulatory protein (probably TetR-family); Controls the expression of a small regulon that may play a role in the utilization of cholesterol.
  
  
 0.844
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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