STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mhuDPossible heme degrading protein MhuD; Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. (105 aa)    
Predicted Functional Partners:
lpqF
Rv3593, (MTCY6F7.01c), len: 452 aa. Probable lpqF,conserved lipoprotein, equivalent to Q9CBI7|MPQF|ML1923 probale secreted protein from Mycobacterium leprae (454 aa), FASTA scores: opt: 2465, E(): 5.7e-144, (79.15% identity in 451 aa overlap). Also similar to Q9KJ91 hypothetical 47.1 KDA protein from Streptomyces clavuligerus (430 aa), FASTA scores: opt: 609, E(): 5.2e-30, (30.3% identity in 350 aa overlap); and some similarity with putative beta-lactamases e.g. Q9RYR7|DRA0241 beta lactamase-related protein from Deinococcus radiodurans (499 aa), FASTA scores: opt: 322,E(): 2.5e-12, (28 [...]
  
  
 0.984
Rv0203
Possible exported protein; Part of a heme-iron acquisition system. Acts by binding heme and delivering it to the membrane proteins MmpL3 and MmpL11. Can use free heme or heme from host hemoglobin.
   
  
 0.870
Rv3591c
Possible hydrolase; Rv3591c, (MTCY6F7.03), len: 257 aa. Possible hydrolase, equivalent to Q9CBI9|ML1921 hypothetical protein from Mycobacterium leprae (256 aa) FASTA scores: opt: 1421,E(): 5.6e-83, (78.5% identity in 251 aa overlap). Also similar to others e.g. Q9K3V0|SCD10.27 putative hydrolase from Streptomyces coelicolor (352 aa), FASTA scores: opt: 193, E(): 5.2e-05, (33.35% identity in 270 aa overlap); O33745|STTC thioesterase from Streptomyces sp (308 aa) FASTA scores: opt: 242, E(): 3.6e-08, (30.35% identity in 270 aa overlap); Q9RK95|SCF1.09 putative hydrolase from Streptomyces [...]
       0.791
Rv0265c
Rv0265c, (MTCY06A4.09c), len: 330 aa. Probable iron-transport lipoprotein, most similar to T36412|5763945|CAB53324.1|AL109974 probable iron-siderophore binding lipoprotein from Streptomyces coelicolor (350 aa); and (N-terminus may be incorrect) to T14166|3560508|AAC82551.1|AF027770 fxuD protein from Mycobacterium smegmatis (420 aa), FASTA scores: opt: 385,E(): 1.5e-16, (32.3% identity in 232 aa overlap). Also similar to AAB97475.1|U02617 DtxR/iron regulated lipoprotein precursor from Corynebacterium diphtheriae (355 aa); FECB_ECOLI|P15028 iron(III) dicitrate-binding periplasmic protein [...]
 
  
 0.708
mmpL11
Probable conserved transmembrane transport protein MmpL11; Part of a heme-iron acquisition system. Receives heme from the heme-binding protein Rv0203 and transports it into the mycobacterial cell. Contributes to virulence. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
   
  
 0.683
hemN
Heme chaperone HemW; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine (By similarity); Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
  
  
 0.663
mmpL3
Possible conserved transmembrane transport protein MmpL3; Transports trehalose monomycolate (TMM) across the inner membrane. Could also be part of a heme-iron acquisition system. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
  
  
 0.626
PPE36
Rv2108, (MTCY261.04), len: 243 aa. PPE36, Member of the Mycobacterium tuberculosis PE family: N-terminus is similar to N-terminal region of Mycobacterium tuberculosis PPE family proteins. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
      
 0.549
PPE62
Rv3533c, (MTCY03C7.23), len: 582 aa. PPE62, Member of the Mycobacterium tuberculosis PPE protein family,similar to many, e.g. O53309|Rv3159c|MTV014.03c (590 aa) FASTA scores: opt: 2289, E(): 2.3e-95, (63.5% identity in 600 aa overlap). Predicted to be an outer membrane protein (See Song et al., 2008).
   
  
 0.543
hycE
Possible formate hydrogenase HycE (FHL); Rv0087, (MTCY251.05), len: 492 aa. Possible hycE (alternate gene name: hevE), formate hydrogenlyase, similar to others. Belongs to the complex I 49 kDa subunit family.
       0.530
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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