STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPE65PPE family protein PPE65; Rv3621c, (MTCY15C10.31, MTCY07H7B.01), len: 413 aa. PPE65, Member of the Mycobacterium tuberculosis PPE family,ala-, gly-rich proteins, similar to many e.g. Q10813|YS92_MYCTU|Rv2892c|MT2959|MTCY274.23c (408 aa) FASTA scores: opt: 955, E(): 1.8e-42, (44.45% identity in 423 aa overlap). (413 aa)    
Predicted Functional Partners:
PE32
Rv3622c, (MTCY15C10.30), len: 99 aa. PE32, Member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu, 2002), but no glycine rich C-terminus present. Similar to others e.g. O53938|Rv1788|MTV049.10 (99 aa),FASTA scores: opt: 376, E(): 7.1e-17, (65.6% identity in 96 aa overlap).
     
 0.956
Rv0373c
Rv0373c, (MTV036.08c), len: 799 aa. Probable carbon monoxide dehydrogenase, large chain, highly similar to others e.g. AAD00363.1| U80806|CUTL carbon monoxide dehydrogenase large subunit CutL protein from Hydrogenophaga pseudoflava (803 aa); S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA carbon-monoxide dehydrogenase large chain (cut operon) from Pseudomonas thermocarboxydovorans (842 aa); C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL carbon-monoxide dehydrogenase large chain (cluster coxMSL) from Pseudomonas/Oligotropha carboxydovorans (809 aa),FASTA scores: opt: 2484, E(): [...]
   
    0.730
PE26
Rv2519, (MTV009.04), len: 492 aa. PE26, Member of the M. tuberculosis PE family (see citation below), highly similar to many e.g. Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c (543 aa),FASTA scores: opt: 848, E(): 3e-30, (39.55% identity in 445 aa overlap).
      
 0.698
Rv3412
Rv3412, (MTCY78.16c), len: 136 aa. Hypothetical protein, strongly similar to Q49742|YY12_MYCLE|ML0386|B1620_F3_131 hypothetical 15.3 KDA protein from Mycobacterium leprae (137 aa), FASTA scores: opt: 933, E(): 6.3e-52, (93.4% identity in 136 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004); To M.leprae ML0386.
   
  
 0.642
arfC
Possible conserved exported or membrane protein; Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. Belongs to the ArfC membrane protein family.
   
  
 0.620
esxW
Rv3620c, (MTCY15C10.32, MTCY07H7B.02, MT3722), len: 98 aa. EsxW, ESAT-6 like protein (see citation below). Member of the M. tuberculosis hypothetical QILSS protein family with Rv1038c, Rv1792, Rv2347c and Rv1197|O05299|ES63_MYCTU|MT1235|MTCI364.09 putative ESAT-6 like protein 3 from Mycobacterium tuberculosis (98 aa),FASTA scores: opt: 638, E(): 2.3e-36, (97.95% identity in 98 aa overlap). Also similar to Q49945|ES6Y_MYCLE putative ESAT-6 like protein Y from Mycobacterium leprae (100 aa),FASTA scores: opt: 370, E(): 2.1e-18, (57.9% identity in 95 aa overlap); etc. Belongs to the ESAT6 [...]
  
    0.612
PE8
Rv1040c, (MTCY10G2.09), len: 275 aa. PE8, Member of the Mycobacterium tuberculosis PE family (see citation below), most similar to AL008967|MTV002_34 Mycobacterium tuberculosis H37Rv (275 aa), FASTA scores: opt: 1111, E(): 0, (68.6% identity in 283 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
    
 
 0.559
esxV
Rv3619c, (MTCY15C10.33, MTCY07H7B.03, MT3721), len: 94 aa. EsxV, ESAT-6 like protein (see citations below),highly similar to many Mycobacterial ESAT-6 like proteins e.g. O53942|ES65_MYCTU putative ESAT-6 like protein 5 from Mycobacterium tuberculosis (94 aa), FASTA scores: opt: 582,E(): 4.4e-33, (92.55% identity in 94 aa overlap); Q49946|ES6X_MYCLE|U1756D putative ESAT-6 like protein X from Mycobacterium leprae (95 aa), FASTA scores: opt: 409,E(): 2.5e-21, (64.15% identity in 92 aa overlap); etc. Strictly identical to P96364|ES61_MYCTU|Rv1037c|MT1066|MTCY10G2.12 putative ESAT-6 like pr [...]
  
    0.550
rplU
50S ribosomal protein L21 RplU; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
   
  
 0.513
PE_PGRS5
PE-PGRS family protein PE_PGRS5; Involved in endoplasmic reticulum (ER) stress-mediated apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Localizes to the host ER, leading to ER stress, disruption of intracellular Ca(2+) homeostasis and increase of nitric oxide (NO) and reactive oxygen species (ROS) levels. Stress response results in caspase-8 activation and apoptosis of macrophage cells. Apoptosis may lead to dissemination of the bacteria, thereby spreading the disease. Belongs to the mycobacterial PE family. PGRS subfamily.
      
 0.453
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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