node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2315c | Rv2323c | Rv2315c | Rv2323c | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | 0.746 |
Rv2315c | cobM | Rv2315c | Rv2071c | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.746 |
Rv2315c | egtB | Rv2315c | Rv3703c | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Ergothioneine is an antioxidant that protects mycobacteria from oxidative stress. | 0.755 |
Rv2315c | end | Rv2315c | Rv0670 | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. Belongs to the AP endonuclease 2 family. | 0.747 |
Rv2315c | lpdA | Rv2315c | Rv3303c | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | NAD(P)H quinone reductase LpdA; May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH. | 0.748 |
Rv2315c | pyrF | Rv2315c | Rv1385 | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | Rv1385, (MTCY21B4.02), len: 274 aa. Probable pyrF,orotidine 5'-phosphate decarboxylase, identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase active site. Belongs to the OMP decarboxylase family. | 0.750 |
Rv2323c | Rv2315c | Rv2323c | Rv2315c | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | 0.746 |
Rv2323c | cobM | Rv2323c | Rv2071c | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.433 |
Rv2323c | egtB | Rv2323c | Rv3703c | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Ergothioneine is an antioxidant that protects mycobacteria from oxidative stress. | 0.688 |
Rv2323c | end | Rv2323c | Rv0670 | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. Belongs to the AP endonuclease 2 family. | 0.754 |
Rv2323c | lpdA | Rv2323c | Rv3303c | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | NAD(P)H quinone reductase LpdA; May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH. | 0.745 |
Rv2323c | pyrF | Rv2323c | Rv1385 | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | Rv1385, (MTCY21B4.02), len: 274 aa. Probable pyrF,orotidine 5'-phosphate decarboxylase, identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase active site. Belongs to the OMP decarboxylase family. | 0.508 |
cobM | Rv2315c | Rv2071c | Rv2315c | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | 0.746 |
cobM | Rv2323c | Rv2071c | Rv2323c | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | 0.433 |
cobM | egtB | Rv2071c | Rv3703c | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Ergothioneine is an antioxidant that protects mycobacteria from oxidative stress. | 0.949 |
cobM | end | Rv2071c | Rv0670 | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. Belongs to the AP endonuclease 2 family. | 0.947 |
cobM | lpdA | Rv2071c | Rv3303c | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | NAD(P)H quinone reductase LpdA; May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH. | 0.746 |
cobM | pyrF | Rv2071c | Rv1385 | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | Rv1385, (MTCY21B4.02), len: 274 aa. Probable pyrF,orotidine 5'-phosphate decarboxylase, identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase active site. Belongs to the OMP decarboxylase family. | 0.949 |
egtB | Rv2315c | Rv3703c | Rv2315c | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Ergothioneine is an antioxidant that protects mycobacteria from oxidative stress. | Conserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity in 432 overlap); and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa), FASTA scores: opt: 876, E():3.1e-46,(42.8% identity in 505 overlap); O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661, E(): 4.3e-33, (29.95% identity in 484 aa overlap [...] | 0.755 |
egtB | Rv2323c | Rv3703c | Rv2323c | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Ergothioneine is an antioxidant that protects mycobacteria from oxidative stress. | Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family. | 0.688 |