STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv3720Possible fatty acid synthase; May be a S-adenosylmethionine-dependent methyltransferase involved in fatty acid metabolism. (420 aa)    
Predicted Functional Partners:
Rv3719
Conserved protein; Rv3719, (MTV025.067), len: 470 aa. Conserved protein, equivalent to O69516|ML2333|MLCB2407.17c hypothetical 51.8 KDA protein from Mycobacterium leprae (459 aa), FASTA scores: opt: 2593, E(): 7.8e-161, (82.75% identity in 458 aa overlap). Also some similarity to Q9CU63|5830417J06RIK hypothetical protein (fragment) from Mus musculus (Mouse) (479 aa) FASTA scores: opt: 454, E(): 6.1e-22, (27.1% identity in 413 aa overlap); Q9HBA8 seladin-1 (unknown) from Homo sapiens (Human) (516 aa),FASTA scores: opt: 444, E(): 2.9e-21, (26.7% identity in 412 aa overlap); O17397|DIMH_C [...]
 
    0.951
Rv3254
Rv3254, (MTCY20B11.29), len: 462 aa. Conserved hypothetical protein, similar to CAC37877|SC1G7.02 putative secreted protein from Streptomyces coelicolor (440 aa),FASTA scores: opt: 606, E(): 6.2e-31, (31.7% identity in 445 aa overlap); O86550|SC1F2.13c hypothetical 50.7 KDA protein from Streptomyces coelicolor (476 aa), FASTA scores: opt: 577, E(): 4.5e-29, (32.5% identity in 400 aa overlap); Q9L0A8|SCC24.09 putative secreted protein from Streptomyces coelicolor (468 aa), FASTA scores: opt: 380,E(): 1.3e-16, (30.7% identity in 391 aa overlap); BAB48792|MLL1411 probable FAD-dependent mo [...]
  
  
 0.808
amiA1
Rv3305c, (MTV016.04c), len: 389 aa. Possible amiA1,N-acyl-L-amino acid amidohydrolase (or peptidase), similar to many proteins e.g. Q9AK43|2SCK8.09 putative peptidase from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1015, E(): 3.9e-54, (50.8% identity in 374 aa overlap); Q9UZ30|PAB0873 amino acid amidohydrolase from Pyrococcus abyssi (383 aa), FASTA scores: opt: 823, E(): 1.6e-42,(38.2% identity in 369 aa overlap); O58453|PH0722 long hypothetical amino acid amidohydrolase from Pyrococcus horikoshii (388 aa), FASTA scores: opt: 815, E(): 4.8e-42,(38.75% identity in 369 aa overl [...]
   
  
 0.803
Rv3718c
Conserved protein; Rv3718c, (MTV025.066c), len: 147 aa. Conserved protein, equivalent to O69517|ML2332|MLCB2407.18 hypothetical 15.5 KDA protein from Mycobacterium leprae (145 aa), FASTA scores: opt: 780, E(): 1.4e-44, (81.95% identity in 144 aa overlap). Also highly similar to Q9ZBJ2|SC9C7.18 conserved hypothetical protein from Streptomyces coelicolor (147 aa) FASTA scores: opt: 475,E(): 1.7e-24, (52.05% identity in 146 aa overlap); and showing some similarity to various proteins e.g. P27538|PR2_PETCR pathogenesis-related protein 2 from Petroselinum crispum (Parsley) (Petroselinum hor [...]
  
    0.774
amiB1
Rv3306c, (MTV016.05c), len: 394 aa. Probable amiB1,aminohydrolase, similar to several belonging to peptidase family M40 (and to hypothetical proteins) e.g. P54983|AMHX_BACSU amidohydrolase AMHX from Bacillus subtilis (389 aa), FASTA scores: opt: 286, E(): 9.9e-10,(26.6% identity in 351 aa overlap); P76052|ABGB_ECOLI Aminobenzoyl-glutamate utilizatio from Escherichia coli (481 aa), FASTA scores: opt: 383, E(): 2.1e-15, (30.5% identity in 328 aa overlap); P44765|YDAJ_HAEIN hypothetical protein HI0584 from Haemophilus influenzae (423 aa), FASTA scores: opt: 297, E(): 2.4e-10, (29.6% ident [...]
      
 0.652
Rv2765
Rv2765, (MTV002.30), len: 245 aa. Probable ala-rich hydrolase, similar to various hydrolases or hypothetical proteins e.g. Q9KYM6|SC9H11.13c putative hydrolase from Streptomyces coelicolor (251 aa), FASTA scores: opt: 630,E(): 1.4e-33, (43.1% identity in 246 aa overlap); Q9A5T9|CC2358 dienelactone hydrolase family protein from Caulobacter crescentus (286 aa), FASTA scores: opt: 592,E(): 4.5e-31, (38.45% identity in 242 aa overlap); Q9FCF1|2SCD46.33 putative hydrolase (dienelactone hydrolase family) from Streptomyces coelicolor (254 aa), FASTA scores: opt: 500, E(): 3.9e-25, (37.7% iden [...]
   
  
 0.651
Rv3304
Conserved protein; Rv3304, (MTV016.03), len: 159 aa. Conserved protein,very similar to Q9CCL6|ML0711 hypothetical protein from Mycobacterium leprae (159 aa), FASTA scores: opt: 1041,E(): 6.1e-62, (91.8% identity in 159 aa overlap); and Q49927|L308_F3_97 from M. leprae (174 aa), FASTA scores: opt: 974, E(): 1.8e-57, (91.2% identity in 149 aa overlap). Also highly similar to Q9AD81|SCK13.10c conserved hypothetical protein from Streptomyces coelicolor (145 aa),FASTA scores: opt: 615, E(): 7.8e-34, (60.55% identity in 147 aa overlap); and shows some similarity to other various hypothetical [...]
  
  
 0.639
Rv3253c
Rv3253c, (MTCY20B11.28c), len: 495 aa. Possible cationic amino acid transporter, integral membrane protein,similar to many e.g. O69844|SC1C3.02 putative cationic amino acid transporter from Streptomyces coelicolor (503 aa), FASTA scores: opt: 1649, E(): 5.8e-92, (52.6% identity in 485 aa overlap); Q9AE69 putative transporter (fragment) from Rhodococcus erythropolis (385 aa), FASTA scores: opt: 1594, E(): 9.7e-89, (62.0% identity in 387 aa overlap); Q9PBD7|XF2207 cationic amino acid transporter from Xylella fastidiosa (483 aa), FASTA scores: opt: 1079, E(): 1.2e-57,(40.55% identity in 4 [...]
  
  
 0.636
Rv3143
Rv3143, (MTCY03A2.15c), len: 133 aa. Probable response regulator, similar to other sensory transduction regulatory proteins e.g. Q9X810|SC6G10.25 from Streptomyces coelicolor (133 aa), FASTA scores: opt: 474, E(): 2.8e-24,(54.15% identity in 120 aa overlap); Q9KZ82|SCE25.04c from Streptomyces coelicolor (225 aa), FASTA scores: opt: 144,E(): 0.016, (32.3% identity in 127 aa overlap); Q9RZT4|DRB0029 from Deinococcus radiodurans (416 aa), FASTA scores: opt: 145, E(): 0.024, (30.65% identity in 124 aa overlap). Similar to other regulatory components of sensory transduction systems.
   
  
 0.551
glpD2
Rv3302c, (MTCI418A.04c, MTV016.01c), len: 585 aa. Probable glpd2, glycerol-3-phosphate dehydrogenase,equivalent to P53435|GLPD_MYCLE|ML0713|L308_C1_179 glycerol-3-phosphate dehydrogenase from Mycobacterium leprae (585 aa), FASTA scores: opt: 3489, E(): 2.2e-198,(90.75% identity in 584 aa overlap). Also highly similar to many e.g. Q9L0I3|SCD63.06 from Streptomyces coelicolor (568 aa), FASTA scores: opt: 2203, E(): 1.6e-122, (59.95% identity in 564 aa overlap); Q9RVK8|DR1019 from Deinococcus radiodurans (522 aa), FASTA scores: opt: 949, E(): 1.4e-48,(37.0% identity in 538 aa overlap); BA [...]
   
  
 0.514
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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