STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vapC50Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB50. (169 aa)    
Predicted Functional Partners:
vapB50
Possible excisionase; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC50.
 
  
 0.994
Rv0298
Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299.
   
  
 0.861
vapC45
Conserved protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB45.
   
  
 0.816
Rv0299
Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312.
   
  
 0.810
vapB48
Possible antitoxin VapB48; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC48.
      
 0.803
Rv2310
Possible excisionase; Rv2310, (MT2372, MTCY3G12.24c), len: 114 aa. Possible excisionase, showing some similarity to others e.g. Q9LCU5 putative excisionase from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 341, E(): 6.6e-15, (48.2% identity in 110 aa overlap); O85865 putative excisionase from Sphingomonas aromaticivorans (152 aa), FASTA scores: opt: 205, E(): 2.2e-06, (41.25% identity in 80 aa overlap); etc. Also similar to Rv3750c|O69717 hypothetical protein from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 228, E(): 6.9e-08, (43.9% identity in 82 aa overlap). Contains [...]
 
    0.800
vapB45
Conserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC45.
 
  
 0.695
higB2
Conserved protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA2. Belongs to the mycobacterial HigB family.
  
  
 0.693
vapC1
Possible toxin VapC1; Toxic component of a type II toxin-antitoxin (TA) system. The cognate antitoxin is VapB1 (By similarity). Has ribonuclease activity.
   
  
 0.669
relK
Toxin RelK; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with antitoxin RelJ (shown only for M.smegmatis). Overexpression also increases the number of rifampcin-tolerant persister cells. Belongs to the YoeB family.
      
 0.659
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.