STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv3776Rv3776, (MTCY13D12.10), len: 519 aa. Conserved hypothetical protein, highly similar to Q10709|YL00_MYCTU|Rv2100|MTCY49.40 hypothetical 58.9 KDA protein from Mycobacterium tuberculosis (550 aa) FASTA scores: opt: 1646, E(): 1.2e-83, (77.85% identity in 510 aa overlap) (homology from potential start at 7744); and similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O33266|Rv0336|MTCY279.03 (503 aa) FASTA scores: opt: 682, E(): 2.2e-30, (41.65% identity in 497 aa overlap). (519 aa)    
Predicted Functional Partners:
Rv3074
Rv3074, (MTCY22D7.07c), len: 424 aa. Conserved hypothetical protein, highly similar but shorter (46 aa) to P71806|Rv1378c|MTCY02B12.12c hypothetical 51.3 KDA protein from Mycobacterium tuberculosis (475 aa), FASTA scores: opt: 2009, E(): 5.8e-113, (72.95% identity in 429 aa overlap); and also similar to other hypothetical mycobacterium proteins e.g. O33266|Rv0336|MTCY279.03 (503 aa), FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity in 381 aa overlap); O33360|Rv0515|MTCY20G10.05 (503 aa),FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity in 381 aa overlap); etc.
  
  
 0.971
Rv1702c
Rv1702c, (MTCI125.24c), len: 454 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat. Similar to other hypothetical proteins inside REP13E12 elements (often in two parts) e.g. Rv0094c|Q50655|MTCY251.13c (317 aa),FASTA scores: opt: 1284, E(): 0, (59.7% identity in 315 aa overlap); and Rv1128c, Rv1945, Rv1148c, etc; Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
  
  
 0.917
Rv1378c
Conserved hypothetical protein; Rv1378c, (MTCY02B12.12c), len: 475 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv3074|MTCY22D7.07C (424 aa), FASTA scores: E(): 0, (73.0% identity in 429 aa overlap).
  
  
 0.852
Rv2100
Rv2100, (MTCY49.40), len: 550 aa. Conserved hypothetical protein. Member of Mycobacterium tuberculosis REP13E12 repeat family with Rv1148c, Rv1945, Rv3467,Rv0094c, Rv1128c, Rv1587c, Rv1702c, Rv3466, Rv1588c; To M.tuberculosis Rv3776.
  
  
0.801
Rv1148c
Rv1148c, (MTCI65.15c), len: 482 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat, nearly identical to other hypothetical Mycobacterium tuberculosis proteins in REP13E12 repeats, although similarity extends upstream past proposed f-Met start. Very similar to other REP13E12 proteins e.g. Rv1945, Rv3467, Rv0094c, Rv1128c etc; Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
  
  
 0.785
Rv1765c
Rv1765c, (MTCY28.31c), len: 365 aa. Conserved hypothetical protein, highly similar to O53461|Rv2015c|MTV018.02c conserved hypothetical protein (418 aa), (97.8% identity in 364 aa overlap). Blast hits with non-is part of sequence submitted under MTU78639.
  
    0.775
Rv2015c
Rv2015c, (MTV018.02c), len: 418 aa. Conserved hypothetical protein. Nearly identical to Mycobacterium tuberculosis Rv1765c|MTCY28.31c, (378 aa), an ORF starting next to ISB9, and ending in IS6110. Different N-terminus chosen and C-terminus differs as that of Rv1765c has been truncated by IS6110. Does not show similarities with transposases. Contains IPR002711 HNH endonuclease,IPR003615 HNH nuclease, IPR003870 DUF222 domains.
  
    0.773
Rv1945
Conserved hypothetical protein; Rv1945, (MTCY09F9.19c), len: 454 aa. Member of Mycobacterium tuberculosis REP13E12 repeat family. Similar to several others, best with Rv1148c|Z95584|MTCI65.15 (482 aa), FASTA score: opt: 2954, E(): 0, (97.1% identity in 454 aa overlap). Contains possible helix-turn-helix motif at aa 74-95 (+2.90 SD).
  
  
 0.762
Rv0094c
Conserved hypothetical protein; Rv0094c, (MTCY251.13c), len: 317 aa. Member of 13E12 repeat family, showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA score: (49.4% identity in 79 aa overlap).
  
    0.760
Rv3467
Rv3467, (MTCY13E12.20), len: 317 aa. Conserved hypothetical ORF in REP13E12 repeat, identical to ORF's from other REP13E12 copies e.g. MTCY251.13c, MTCI65.15c,MTCY09F9.19, cMTCY336.17. Also identical to Mycobacterium bovis Q50655 hypothetical 34.6 kDa protein (317 aa) in identical repeat.
  
    0.757
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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