STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv3789GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. (121 aa)    
Predicted Functional Partners:
dprE2
Decaprenylphosphoryl-D-2-keto erythro pentose reductase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probab [...]
 
  
 0.966
dprE1
Decaprenylphosphoryl-beta-D-ribose 2'-oxidase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through [...]
 
  
 0.965
embC
Probable arabinosyltransferase C; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
 
  
 0.964
aftA
Arabinofuranosyltransferase AftA; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. Belongs to the glycosyltransf [...]
 
  
 0.911
embA
Probable arabinosyltransferase A; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
 
  
 0.882
embB
Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
 
  
 0.874
ubiA
Decaprenyl-phosphate phosphoribosyltransferase; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). The enzyme favors polyprenyl phosphate with 50-60 carbon atoms uses C-75 polyprenyl phosphate less efficiently than C-50 or C-60. Belongs to the UbiA prenyltransferase family.
 
  
 0.798
Rv3788
Hypothetical protein; Rv3788, (MTCY13D12.22), len: 161 aa. Hypothetical unknown protein.
  
    0.776
rfbD
Rv3783, (MTCY13D12.17), len: 280 aa. Probable rfbD,polysaccharide-transport integral membrane protein ABC transporter (see Braibant et al., 2000), involved in O-antigen/lipopolysaccharides (LPS) transport, equivalent to Q9CDA2|ML0112 putative ABC transporter component from Mycobacterium leprae (276 aa), FASTA scores: opt: 1646,E(): 4e-102, (84.3% identity in 280 aa overlap). Also highly similar to Q9PAF1|XF2567 ABC transporter permease protein from Xylella fastidiosa (267 aa), FASTA scores: opt: 723, E(): 7.6e-41, (41.3% identity in 259 aa overlap); and similar to others e.g. Q56902|RF [...]
 
  
 0.754
Rv2073c
Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
    0.735
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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