node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3850 | espR | Rv3850 | Rv3849 | Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004) | Nucleoid-associated protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression | 0.714 |
eccCa1 | espA | Rv3870 | Rv3616c | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | 0.801 |
eccCa1 | espB | Rv3870 | Rv3881c | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | ESX-1 secretion-associated protein EspB; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages | 0.915 |
eccCa1 | espC | Rv3870 | Rv3615c | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | ESX-1 secretion-associated protein EspC; Required for ESX-1 function. Required for either stability or expression of EspA | 0.788 |
eccCa1 | espD | Rv3870 | Rv3614c | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | ESX-1 secretion-associated protein EspD; Required for ESX-1 function. Required for the maintenance of adequate cellular levels of both EspA and EspC. Facilitates EsxA secretion | 0.914 |
eccCa1 | espR | Rv3870 | Rv3849 | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | Nucleoid-associated protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression | 0.724 |
eccCa1 | esxA | Rv3870 | Rv3875 | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | 6 kDa early secretory antigenic target; A secreted protein that plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. Acts as a strong host (human) T-cell antigen. Inhibits IL-12 p40 (IL12B) and TNF-alpha expression by infected host (mouse) macrophages, reduces the nitric oxide response by about 75%. In mice previously exposed to the bacterium, elicits high level of IFN- gamma production by T-cells upon subsequent challenge by M.tuberculosis, in the first phase of a protective immune resp [...] | 0.972 |
eccCa1 | esxB | Rv3870 | Rv3874 | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | ESAT-6-like protein EsxB; A secreted protein. Acts as a strong host (human) T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA. EsxA and EsxA-EsxB are cytotoxic to pneumocytes. EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose- dependent manner, monocytes and [...] | 0.974 |
espA | eccCa1 | Rv3616c | Rv3870 | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | 0.801 |
espA | espB | Rv3616c | Rv3881c | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | ESX-1 secretion-associated protein EspB; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages | 0.875 |
espA | espC | Rv3616c | Rv3615c | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | ESX-1 secretion-associated protein EspC; Required for ESX-1 function. Required for either stability or expression of EspA | 0.955 |
espA | espD | Rv3616c | Rv3614c | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | ESX-1 secretion-associated protein EspD; Required for ESX-1 function. Required for the maintenance of adequate cellular levels of both EspA and EspC. Facilitates EsxA secretion | 0.932 |
espA | espR | Rv3616c | Rv3849 | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | Nucleoid-associated protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression | 0.877 |
espA | esxA | Rv3616c | Rv3875 | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | 6 kDa early secretory antigenic target; A secreted protein that plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. Acts as a strong host (human) T-cell antigen. Inhibits IL-12 p40 (IL12B) and TNF-alpha expression by infected host (mouse) macrophages, reduces the nitric oxide response by about 75%. In mice previously exposed to the bacterium, elicits high level of IFN- gamma production by T-cells upon subsequent challenge by M.tuberculosis, in the first phase of a protective immune resp [...] | 0.877 |
espA | esxB | Rv3616c | Rv3874 | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | ESAT-6-like protein EsxB; A secreted protein. Acts as a strong host (human) T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA. EsxA and EsxA-EsxB are cytotoxic to pneumocytes. EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose- dependent manner, monocytes and [...] | 0.877 |
espA | phoP | Rv3616c | Rv0757 | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | Rv0757, (MTCY369.02), len: 247 aa. Possible phoP,two component system response phosphate regulon transcriptional regulator (see citations below), highly similar to various transcriptional regulators e.g. CAC32360.1|AL583945 putative two component system response regulator from Streptomyces coelicolor (271 aa); T45446 probable two-component response regulator from Mycobacterium leprae (253 aa); and similar to phoP proteins e.g. P13792|PHOP_BACSU alkaline phosphatase synthesis transcription regulatory protein from Bacillus subtilis (240 aa), FASTA scores: opt: 594, E(): 2.3e-33, (41.0% i [...] | 0.834 |
espB | eccCa1 | Rv3881c | Rv3870 | ESX-1 secretion-associated protein EspB; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP- 10) | 0.915 |
espB | espA | Rv3881c | Rv3616c | ESX-1 secretion-associated protein EspB; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages | ESX-1 secretion-associated protein EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP- 10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm | 0.875 |
espB | espC | Rv3881c | Rv3615c | ESX-1 secretion-associated protein EspB; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages | ESX-1 secretion-associated protein EspC; Required for ESX-1 function. Required for either stability or expression of EspA | 0.806 |
espB | espD | Rv3881c | Rv3614c | ESX-1 secretion-associated protein EspB; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages | ESX-1 secretion-associated protein EspD; Required for ESX-1 function. Required for the maintenance of adequate cellular levels of both EspA and EspC. Facilitates EsxA secretion | 0.888 |