node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0688 | rraA | Rv0688 | Rv3853 | Rv0688, (MTCY210.05), len: 406 aa. Putative ferredoxin reductase, highly similar to others e.g. BAB55881.1|AB054975 ferredoxin reductase from Terrabacter sp. DBF63 (410 aa); CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); PPU24215_8|Q51973 P-cumate dioxygenase ferredoxin reductase subunit from Pseudomonas putida (402 aa), FASTA scores: opt: 738, E(): 0, (38.8% identity in 330 aa overlap); etc. Also similar to Rv0253 and Rv1869c from Mycobacterium tuberculosis. Could belong to the bacterial type ferredoxin family. | Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Belongs to the class II aldolase/RraA-like family. | 0.409 |
Rv3850 | Rv3851 | Rv3850 | Rv3851 | Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Possible membrane protein; Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein. | 0.960 |
Rv3850 | espR | Rv3850 | Rv3849 | Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. | 0.854 |
Rv3850 | hns | Rv3850 | Rv3852 | Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 histone H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183,E(): 0.091, (34.85% identity in 109 aa overlap); etc. | 0.764 |
Rv3850 | rraA | Rv3850 | Rv3853 | Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Belongs to the class II aldolase/RraA-like family. | 0.752 |
Rv3851 | Rv3850 | Rv3851 | Rv3850 | Possible membrane protein; Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein. | Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.960 |
Rv3851 | espR | Rv3851 | Rv3849 | Possible membrane protein; Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein. | ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. | 0.531 |
Rv3851 | hns | Rv3851 | Rv3852 | Possible membrane protein; Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein. | Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 histone H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183,E(): 0.091, (34.85% identity in 109 aa overlap); etc. | 0.562 |
Rv3851 | rraA | Rv3851 | Rv3853 | Possible membrane protein; Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein. | Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Belongs to the class II aldolase/RraA-like family. | 0.528 |
deaD | rraA | Rv1253 | Rv3853 | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog); DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. | Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Belongs to the class II aldolase/RraA-like family. | 0.489 |
espR | Rv3850 | Rv3849 | Rv3850 | ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. | Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.854 |
espR | Rv3851 | Rv3849 | Rv3851 | ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. | Possible membrane protein; Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein. | 0.531 |
espR | hns | Rv3849 | Rv3852 | ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. | Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 histone H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183,E(): 0.091, (34.85% identity in 109 aa overlap); etc. | 0.618 |
espR | rraA | Rv3849 | Rv3853 | ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. | Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Belongs to the class II aldolase/RraA-like family. | 0.516 |
hns | Rv3850 | Rv3852 | Rv3850 | Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 histone H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183,E(): 0.091, (34.85% identity in 109 aa overlap); etc. | Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.764 |
hns | Rv3851 | Rv3852 | Rv3851 | Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 histone H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183,E(): 0.091, (34.85% identity in 109 aa overlap); etc. | Possible membrane protein; Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein. | 0.562 |
hns | espR | Rv3852 | Rv3849 | Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 histone H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183,E(): 0.091, (34.85% identity in 109 aa overlap); etc. | ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. | 0.618 |
hns | rraA | Rv3852 | Rv3853 | Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 histone H1 from Triticum aestivum (Wheat) (288 aa), FASTA scores: opt: 183,E(): 0.091, (34.85% identity in 109 aa overlap); etc. | Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Belongs to the class II aldolase/RraA-like family. | 0.879 |
icl1 | rraA | Rv0467 | Rv3853 | Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity). | Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Belongs to the class II aldolase/RraA-like family. | 0.540 |
mscL | rraA | Rv0985c | Rv3853 | Possible large-conductance ion mechanosensitive channel MscL; Channel that opens in response to stretch forces in the membrane lipid bilayer. The force required to trigger channel opening depends on the nature of the membrane lipids; the presence of phosphatidylinositol enhances mechanosensitivity of the channel. May participate in the regulation of osmotic pressure changes within the cell. | Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Belongs to the class II aldolase/RraA-like family. | 0.429 |