node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3446c | espB | Rv3446c | Rv3881c | Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein. | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | 0.445 |
Rv3446c | espH | Rv3446c | Rv3867 | Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein. | Rv3867, (MTV027.02), len: 183 aa. EspH, ESX-1 secretion-associated protein, highly similar to the hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa) FASTA scores: opt: 403, E(): 1.8e-18, (48.2% identity in 166 aa overlap); Q49730|ML0407|B1620_C3_264|MLCL383.03 (216 aa), FASTA scores: opt: 517, E(): 1.7e-25, (51.45% identity in 175 aa overlap); and O33090|MLCB628.19c (338 aa), FASTA scores: opt: 403, E(): 3.4e-18, (48.2% identity in 166 aa overlap). Also highly similar to O06269|Rv3614c|MTCY07H7B.08 hypothetical 19.8 KDA protein from Mycobacterium tuberculosis (184 [...] | 0.597 |
Rv3446c | espI | Rv3446c | Rv3876 | Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein. | ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein; Required to repress ESX-1-mediated secretion under low ATP conditions. This function requires the ATP-binding motif. | 0.537 |
Rv3446c | espJ | Rv3446c | Rv3878 | Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein. | ESX-1 secretion-associated protein EspJ. Conserved alanine rich protein; Could be involved in regulation of growth and intracellular survival. | 0.527 |
Rv3446c | espK | Rv3446c | Rv3879c | Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein. | ESX-1 secretion-associated protein EspK. Alanine and proline rich protein; May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1. | 0.604 |
Rv3446c | espL | Rv3446c | Rv3880c | Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein. | ESX-1 secretion-associated protein EspL; Probably plays a role in host phagosome maturation arrest. | 0.664 |
eccE1 | espB | Rv3882c | Rv3881c | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | 0.923 |
eccE1 | espI | Rv3882c | Rv3876 | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein; Required to repress ESX-1-mediated secretion under low ATP conditions. This function requires the ATP-binding motif. | 0.702 |
eccE1 | espK | Rv3882c | Rv3879c | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | ESX-1 secretion-associated protein EspK. Alanine and proline rich protein; May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1. | 0.937 |
eccE1 | espL | Rv3882c | Rv3880c | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | ESX-1 secretion-associated protein EspL; Probably plays a role in host phagosome maturation arrest. | 0.889 |
eccE1 | mycP1 | Rv3882c | Rv3883c | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | Mycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice; Belongs to the peptidase S8 family. | 0.996 |
espB | Rv3446c | Rv3881c | Rv3446c | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein. | 0.445 |
espB | eccE1 | Rv3881c | Rv3882c | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | 0.923 |
espB | espF | Rv3881c | Rv3865 | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | Rv3865, (MTCY01A6.03c), len: 103 aa. EspF, ESX-1 secretion-associated protein, showing some similarity to O06268|Rv3615c|MTCY07H7B.07 hypothetical 10.8 KDA protein from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 198, E(): 7.5e-07, (36.25% identity in 102 aa overlap); Q49723|ML0406|B1620_C2_214|MLCL383.02 hypothetical 11.1 KDA protein from Mycobacterium leprae (106 aa), FASTA scores: opt: 154, E(): 0.00071, (31.05% identity in 103 aa overlap); Belongs to the EspC family. | 0.733 |
espB | espH | Rv3881c | Rv3867 | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | Rv3867, (MTV027.02), len: 183 aa. EspH, ESX-1 secretion-associated protein, highly similar to the hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa) FASTA scores: opt: 403, E(): 1.8e-18, (48.2% identity in 166 aa overlap); Q49730|ML0407|B1620_C3_264|MLCL383.03 (216 aa), FASTA scores: opt: 517, E(): 1.7e-25, (51.45% identity in 175 aa overlap); and O33090|MLCB628.19c (338 aa), FASTA scores: opt: 403, E(): 3.4e-18, (48.2% identity in 166 aa overlap). Also highly similar to O06269|Rv3614c|MTCY07H7B.08 hypothetical 19.8 KDA protein from Mycobacterium tuberculosis (184 [...] | 0.713 |
espB | espI | Rv3881c | Rv3876 | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein; Required to repress ESX-1-mediated secretion under low ATP conditions. This function requires the ATP-binding motif. | 0.843 |
espB | espJ | Rv3881c | Rv3878 | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | ESX-1 secretion-associated protein EspJ. Conserved alanine rich protein; Could be involved in regulation of growth and intracellular survival. | 0.791 |
espB | espK | Rv3881c | Rv3879c | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | ESX-1 secretion-associated protein EspK. Alanine and proline rich protein; May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1. | 0.989 |
espB | espL | Rv3881c | Rv3880c | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | ESX-1 secretion-associated protein EspL; Probably plays a role in host phagosome maturation arrest. | 0.995 |
espB | mycP1 | Rv3881c | Rv3883c | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | Mycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice; Belongs to the peptidase S8 family. | 0.950 |