node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PE36 | PPE63 | Rv3893c | Rv3539 | Rv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). | Rv3539, (MTCY03C7.17c), len: 479 aa. PPE63, Member of the Mycobacterium tuberculosis PPE protein family,similar to many e.g. O53949|Rv1800|MTV049.22 (655 aa),FASTA scores: opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa overlap); etc. | 0.630 |
PE36 | PPE69 | Rv3893c | Rv3892c | Rv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | 0.833 |
PE36 | eccC2 | Rv3893c | Rv3894c | Rv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). | Rv3894c, (MTCY15F10.18), len: 1396 aa. EccC2, esx conserved component, ESX-2 type VII secretion system protein, possible membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa),FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 hypothetical protein from Mycobacterium leprae (597 aa), FASTA scores: opt: 537, E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane prote [...] | 0.707 |
PE36 | esxC | Rv3893c | Rv3890c | Rv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). | Rv3890c, (MT4005, MTCY15F10.22), len: 95 aa. EsxC,ESAT-6 like protein (see Gey Van Pittius et al., 2001),equivalent to Q9K548|ES6B_MYCPA putative ESAT-6 like protein 11 (ORF3890C) from Mycobacterium paratuberculosis (95 aa), FASTA scores: opt: 490, E(): 3.3e-26, (76.85% identity in 95 aa overlap). Belongs to the ESAT6 family. | 0.493 |
PE36 | esxD | Rv3893c | Rv3891c | Rv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). | Possible ESAT-6 like protein EsxD; Rv3891c, (MTCY15F10.21), len: 107 aa (first GTG taken). EsxD, ESAT-6 like protein, equivalent to Q9K547 hypothetical 10.3 KDA protein (fragment) from Mycobacterium paratuberculosis (100 aa), FASTA scores: opt: 498, E(): 1.7e-26, (77.25% identity in 101 aa overlap). Seems to belong to the ESAT6 family (see Gey Van Pittius et al.,2001). | 0.501 |
PE_PGRS37 | PPE59 | Rv2126c | Rv3429 | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | Rv3429, (MTCY77.01), len: 178 aa. PPE59, Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa),FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end); etc. | 0.439 |
PE_PGRS37 | PPE69 | Rv2126c | Rv3892c | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | 0.511 |
PE_PGRS37 | fadH | Rv2126c | Rv1175c | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | Rv1175c, (MTV005.11c), len: 674 aa. Probable fadH,NADPH-dependent 2,4-dienoyl-CoA reductase, highly similar to others e.g. NP_251782.1|NC_002516 2,4-dienoyl-CoA reductase FadH1 from Pseudomonas aeruginosa (679 aa); CAC01564.1|AL391039 2,4-dienoyl-CoA reductase [NADPH] from Streptomyces coelicolor (671 aa); P42593|FADH_ECOLI 2,4-dienoyl-CoA reductase from Escherichia coli (671 aa),FASTA scores: opt: 2344, E(): 0, (53.1% identity in 671 aa overlap); etc. Also similar to Rv3359|MTV004.16 putative oxidoreductase from Mycobacterium tuberculosis (396 aa). | 0.511 |
PE_PGRS37 | lppB | Rv2126c | Rv2544 | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | Rv2544, (MTCY159.12c), len: 220 aa. Probable lppB,conserved lipoprotein, highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 putative lipoprotein LPPA from Mycobacterium tuberculosis (219 aa),FASTA scores: opt: 1242, E(): 4.8e-72, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.510 |
PPE57 | PPE69 | Rv3425 | Rv3892c | PPE family protein PPE57; Plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2). Interacts with TLR2, leading to the subsequent activation of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa-B) signaling pathways. Induces macrophage activation by augmenting the expression of several cell surface molecules (CD40, CD80, CD86 and MHC class II) and pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-12p40) within macrophages. Also participates in adaptive immunity by directing Th1- polarised immune respo [...] | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | 0.512 |
PPE59 | PE_PGRS37 | Rv3429 | Rv2126c | Rv3429, (MTCY77.01), len: 178 aa. PPE59, Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa),FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end); etc. | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | 0.439 |
PPE59 | PPE69 | Rv3429 | Rv3892c | Rv3429, (MTCY77.01), len: 178 aa. PPE59, Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa),FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end); etc. | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | 0.622 |
PPE59 | lppB | Rv3429 | Rv2544 | Rv3429, (MTCY77.01), len: 178 aa. PPE59, Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa),FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end); etc. | Rv2544, (MTCY159.12c), len: 220 aa. Probable lppB,conserved lipoprotein, highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 putative lipoprotein LPPA from Mycobacterium tuberculosis (219 aa),FASTA scores: opt: 1242, E(): 4.8e-72, (87.15% identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.466 |
PPE63 | PE36 | Rv3539 | Rv3893c | Rv3539, (MTCY03C7.17c), len: 479 aa. PPE63, Member of the Mycobacterium tuberculosis PPE protein family,similar to many e.g. O53949|Rv1800|MTV049.22 (655 aa),FASTA scores: opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa overlap); etc. | Rv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). | 0.630 |
PPE63 | PPE69 | Rv3539 | Rv3892c | Rv3539, (MTCY03C7.17c), len: 479 aa. PPE63, Member of the Mycobacterium tuberculosis PPE protein family,similar to many e.g. O53949|Rv1800|MTV049.22 (655 aa),FASTA scores: opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa overlap); etc. | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | 0.440 |
PPE69 | PE36 | Rv3892c | Rv3893c | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | Rv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6% identity in 73 aa overlap). | 0.833 |
PPE69 | PE_PGRS37 | Rv3892c | Rv2126c | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family. | 0.511 |
PPE69 | PPE57 | Rv3892c | Rv3425 | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | PPE family protein PPE57; Plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2). Interacts with TLR2, leading to the subsequent activation of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa-B) signaling pathways. Induces macrophage activation by augmenting the expression of several cell surface molecules (CD40, CD80, CD86 and MHC class II) and pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-12p40) within macrophages. Also participates in adaptive immunity by directing Th1- polarised immune respo [...] | 0.512 |
PPE69 | PPE59 | Rv3892c | Rv3429 | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | Rv3429, (MTCY77.01), len: 178 aa. PPE59, Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa),FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end); etc. | 0.622 |
PPE69 | PPE63 | Rv3892c | Rv3539 | Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa), FASTA scores: opt: 348,E(): 2.2e-08, (26.6% identity in 380 aa overlap). | Rv3539, (MTCY03C7.17c), len: 479 aa. PPE63, Member of the Mycobacterium tuberculosis PPE protein family,similar to many e.g. O53949|Rv1800|MTV049.22 (655 aa),FASTA scores: opt: 914, E(): 7.3e-47, (37.55% identity in 490 aa overlap); etc. | 0.440 |