node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3920c | gid | Rv3920c | Rv3919c | Rv3920c, (MTV028.11c), len: 187 aa. Conserved protein, similar to jag protein, equivalent to Q9L7M2 hypothetical 20.1 KDA protein from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: 1004, E(): 7.3e-52, (85.05% identity in 187 aa overlap); and Q50204|ML2709 hypothetical protein similar to jag protein SPOIIIJ associated protein in bacillus subtilis from Mycobacterium leprae (193 aa), FASTA scores: opt: 871, E(): 4.4e-44, (73.05% identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|jag jag-like protein from Streptomyces coelicolor (170 aa [...] | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | 0.947 |
Rv3920c | parA | Rv3920c | Rv3918c | Rv3920c, (MTV028.11c), len: 187 aa. Conserved protein, similar to jag protein, equivalent to Q9L7M2 hypothetical 20.1 KDA protein from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: 1004, E(): 7.3e-52, (85.05% identity in 187 aa overlap); and Q50204|ML2709 hypothetical protein similar to jag protein SPOIIIJ associated protein in bacillus subtilis from Mycobacterium leprae (193 aa), FASTA scores: opt: 871, E(): 4.4e-44, (73.05% identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|jag jag-like protein from Streptomyces coelicolor (170 aa [...] | Rv3918c, (MTV028.09c), len: 347 aa. Probable parA,chromosome partitioning protein, highly similar to Q9CCX7|para|ML2707 putative cell division protein from Mycobacterium leprae (351 aa), FASTA scores: opt: 1679,E(): 2.9e-93, (78.1% identity in 347 aa overlap). Also highly similar to others e.g. Q9RFM1|para para protein from Streptomyces coelicolor (357 aa), FASTA scores: opt: 1197,E(): 2e-64, (60.45% identity in 306 aa overlap); Q98DZ3|MLL4479|para chromosome partitioning protein from Rhizobium loti (Mesorhizobium loti) (266 aa), FASTA scores: opt: 835, E(): 7.2e-43, (50.95% identity i [...] | 0.771 |
Rv3920c | parB | Rv3920c | Rv3917c | Rv3920c, (MTV028.11c), len: 187 aa. Conserved protein, similar to jag protein, equivalent to Q9L7M2 hypothetical 20.1 KDA protein from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: 1004, E(): 7.3e-52, (85.05% identity in 187 aa overlap); and Q50204|ML2709 hypothetical protein similar to jag protein SPOIIIJ associated protein in bacillus subtilis from Mycobacterium leprae (193 aa), FASTA scores: opt: 871, E(): 4.4e-44, (73.05% identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|jag jag-like protein from Streptomyces coelicolor (170 aa [...] | Probable chromosome partitioning protein ParB; Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity); Belongs to the ParB family. | 0.842 |
embB | gid | Rv3795 | Rv3919c | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | 0.888 |
embB | gyrA | Rv3795 | Rv0006 | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state, while in the absence of ATP it relaxes supercoiled dsDNA. Also catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Gyrase from M.tuberculosis has higher decatenation than supercoiling activity compared to E.coli; as M.tuberculosis only has 1 type II topoisomerase, gyrase has to fulfill the decatenation function of topoisomerase IV as well. At comparable con [...] | 0.965 |
embB | gyrB | Rv3795 | Rv0005 | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state, while in the absence of ATP it relaxes supercoiled dsDNA. . Also catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Gyrase from M.tuberculosis has higher decatenation than supercoiling activity compared to E.coli; as M.tuberculosis only has 1 type II topoisomerase, gyrase has to fulfill the decatenation function of topoisomerase IV as well. At comparable c [...] | 0.962 |
embB | pncA | Rv3795 | Rv2043c | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | Pyrazinamidase/nicotinamidase PncA (PZase); Catalyzes the deamidation of nicotinamide (NAM) into nicotinate. Likely functions in the cyclical salvage pathway for production of NAD from nicotinamide (By similarity). Belongs to the isochorismatase family. | 0.965 |
embB | rpoB | Rv3795 | Rv0667 | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.965 |
embB | rpsL | Rv3795 | Rv0682 | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | 30S ribosomal protein S12 RpsL; With S4 and S5 plays an important role in translational accuracy. | 0.965 |
embB | tlyA | Rv3795 | Rv1694 | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | 2'-O-methyltransferase TlyA; Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy. Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Is likely involved in ribosomal biogenesis. Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes. Belongs to the TlyA family. | 0.854 |
gid | Rv3920c | Rv3919c | Rv3920c | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | Rv3920c, (MTV028.11c), len: 187 aa. Conserved protein, similar to jag protein, equivalent to Q9L7M2 hypothetical 20.1 KDA protein from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: 1004, E(): 7.3e-52, (85.05% identity in 187 aa overlap); and Q50204|ML2709 hypothetical protein similar to jag protein SPOIIIJ associated protein in bacillus subtilis from Mycobacterium leprae (193 aa), FASTA scores: opt: 871, E(): 4.4e-44, (73.05% identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|jag jag-like protein from Streptomyces coelicolor (170 aa [...] | 0.947 |
gid | embB | Rv3919c | Rv3795 | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | 0.888 |
gid | gyrA | Rv3919c | Rv0006 | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state, while in the absence of ATP it relaxes supercoiled dsDNA. Also catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Gyrase from M.tuberculosis has higher decatenation than supercoiling activity compared to E.coli; as M.tuberculosis only has 1 type II topoisomerase, gyrase has to fulfill the decatenation function of topoisomerase IV as well. At comparable con [...] | 0.933 |
gid | gyrB | Rv3919c | Rv0005 | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state, while in the absence of ATP it relaxes supercoiled dsDNA. . Also catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Gyrase from M.tuberculosis has higher decatenation than supercoiling activity compared to E.coli; as M.tuberculosis only has 1 type II topoisomerase, gyrase has to fulfill the decatenation function of topoisomerase IV as well. At comparable c [...] | 0.877 |
gid | parA | Rv3919c | Rv3918c | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | Rv3918c, (MTV028.09c), len: 347 aa. Probable parA,chromosome partitioning protein, highly similar to Q9CCX7|para|ML2707 putative cell division protein from Mycobacterium leprae (351 aa), FASTA scores: opt: 1679,E(): 2.9e-93, (78.1% identity in 347 aa overlap). Also highly similar to others e.g. Q9RFM1|para para protein from Streptomyces coelicolor (357 aa), FASTA scores: opt: 1197,E(): 2e-64, (60.45% identity in 306 aa overlap); Q98DZ3|MLL4479|para chromosome partitioning protein from Rhizobium loti (Mesorhizobium loti) (266 aa), FASTA scores: opt: 835, E(): 7.2e-43, (50.95% identity i [...] | 0.982 |
gid | parB | Rv3919c | Rv3917c | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | Probable chromosome partitioning protein ParB; Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity); Belongs to the ParB family. | 0.983 |
gid | pncA | Rv3919c | Rv2043c | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | Pyrazinamidase/nicotinamidase PncA (PZase); Catalyzes the deamidation of nicotinamide (NAM) into nicotinate. Likely functions in the cyclical salvage pathway for production of NAD from nicotinamide (By similarity). Belongs to the isochorismatase family. | 0.868 |
gid | rpoB | Rv3919c | Rv0667 | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.954 |
gid | rpsL | Rv3919c | Rv0682 | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | 30S ribosomal protein S12 RpsL; With S4 and S5 plays an important role in translational accuracy. | 0.966 |
gid | tlyA | Rv3919c | Rv1694 | Probable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. | 2'-O-methyltransferase TlyA; Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy. Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Is likely involved in ribosomal biogenesis. Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes. Belongs to the TlyA family. | 0.919 |