STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pin1-2Peptidyl-prolyl cis-trans isomerase. (159 aa)    
Predicted Functional Partners:
irf3
IRF tryptophan pentad repeat domain-containing protein.
   
 0.967
Irf3.L
IRF tryptophan pentad repeat domain-containing protein.
   
 0.967
pin1
Peptidyl-prolyl cis-trans isomerase.
  
  
 
0.900
A0A1L8H4Q1
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.796
Wee1.S
Wee1-like protein kinase.
    
 
 0.795
Tp53.L
P53 domain-containing protein.
    
 0.789
A0A1L8GQN9
Protein kinase domain-containing protein.
    
 0.783
Wee2
Wee1-like protein kinase.
    
 
 0.773
clpp
ATP-dependent Clp protease proteolytic subunit.
  
 
 0.741
pin4
Peptidyl-prolyl cis-trans isomerase.
  
  
0.628
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
Server load: low (36%) [HD]