STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sox7Transcription factor Sox-7; Transcription factor. Binds to the DNA sequence 5'- AACAAT-3'. Acts downstream of vegt and upstream of nodal signaling to promote endodermal and mesodermal differentiation by promoting vegt-induced expression of both endodermal genes (including endodermin) and mesodermal genes (including snai1/snail and snai2/slug). Induces expression of multiple nodal genes (including nodal, nodal2, nodal4, nodal5 and nodal6) and binds directly to sites within the promoter of the nodal5 gene. The endodermal and mesodermal specification pathways then interact to initiate car [...] (362 aa)    
Predicted Functional Partners:
ctnnb1
Catenin (cadherin-associated protein), beta 1, 88kDa
    
 0.933
gata6
Zinc-finger transcription factor Gata6; GATA binding protein 6
   
 
 0.754
pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
      
 0.732
gata4
GATA binding protein 4
    
 
 0.710
msra.1
Methionine sulfoxide reductase A, gene 1
      
 0.679
pou5f3.1
POU class V protein oct-91
    
 
 0.643
pou5f3.2
POU domain, class 5, transcription factor 1.1; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Activates transcription when directly bound to the octamer DNA sequence, but can form repression complexes with other proteins at the promoter site to inhibit transcription. Binds to the promoter of the vent2-B gene to activate transcription when in the presence of other BMP signaling factors also bound to the promoter. Inhibits the competence of ectodermal cells to respond to BMP during embryogenesis thereby inhibiting epidermal differentiation and promoting neural ind [...]
    
 
 0.607
mtmr9
Myotubularin related protein 9; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily
      
 0.570
pinx1
Uncharacterized protein; PIN2/TERF1 interacting, telomerase inhibitor 1
 
    
 0.560
qsox1
Quiescin Q6 sulfhydryl oxidase 1
      
 0.557
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. (Silurana) tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, Xenopus tropicalis, western clawed frog
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