STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vps35lProprotein convertase subtilisin/kexin type 7. (963 aa)    
Predicted Functional Partners:
ccdc22
Coiled-coil domain-containing protein 22; May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).
    
 
 0.892
vps29
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective com [...]
    
 
 0.883
ccdc93
Coiled-coil domain-containing protein 93; May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family.
    
 
 0.847
commd1
Protein serine kinase H1.
    
 
 0.829
vps26c
BAI1-associated protein 2.
   
 
 0.820
commd2
LOC100127739 protein.
    
 
 0.757
COMMD3
COMM domain containing 3.
    
 
 0.727
commd4
COMM domain-containing protein.
    
 
 0.680
commd10
Prostaglandin E synthase 2.
    
 
 0.546
FAM135B
Family with sequence similarity 135 member B.
   
  
 0.518
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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