STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
notch2FTO alpha-ketoglutarate dependent dioxygenase. (2455 aa)    
Predicted Functional Partners:
jag1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.981
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.974
dlc
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.959
dll1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.959
lfng
Beta-1,3-N-acetylglucosaminyltransferase.
    
 0.927
dtx1
Rhomboid domain containing 2.
    
 0.926
dtx2
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.
    
 0.926
numb
PID domain-containing protein.
   
 0.925
NUMBL
NUMB like endocytic adaptor protein.
   
 0.925
psen1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.923
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.