node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC101732197 | coq2 | ENSXETP00000019543 | ENSXETP00000025425 | Cytochrome c oxidase subunit Vb, gene 1. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.597 |
LOC101732197 | dhdds | ENSXETP00000019543 | ENSXETP00000037669 | Cytochrome c oxidase subunit Vb, gene 1. | Alkyl transferase; Belongs to the UPP synthase family. | 0.491 |
LOC101732197 | fdft1 | ENSXETP00000019543 | ENSXETP00000023788 | Cytochrome c oxidase subunit Vb, gene 1. | Ankyrin repeat and SOCS box containing 1. | 0.689 |
LOC101732197 | ggps1 | ENSXETP00000019543 | ENSXETP00000046271 | Cytochrome c oxidase subunit Vb, gene 1. | Protocadherin 8; Belongs to the FPP/GGPP synthase family. | 0.556 |
LOC101732197 | hmgcs1 | ENSXETP00000019543 | ENSXETP00000037965 | Cytochrome c oxidase subunit Vb, gene 1. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.504 |
LOC101732197 | idi1 | ENSXETP00000019543 | ENSXETP00000007983 | Cytochrome c oxidase subunit Vb, gene 1. | DNA replication ATP-dependent helicase/nuclease DNA2. | 0.653 |
LOC101732197 | lss | ENSXETP00000019543 | ENSXETP00000043114 | Cytochrome c oxidase subunit Vb, gene 1. | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. | 0.630 |
LOC101732197 | mvd | ENSXETP00000019543 | ENSXETP00000046279 | Cytochrome c oxidase subunit Vb, gene 1. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.717 |
LOC101732197 | ndufaf6 | ENSXETP00000019543 | ENSXETP00000005815 | Cytochrome c oxidase subunit Vb, gene 1. | Canopy FGF signaling regulator 2. | 0.572 |
LOC101732197 | ubiad1 | ENSXETP00000019543 | ENSXETP00000010455 | Cytochrome c oxidase subunit Vb, gene 1. | UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzym [...] | 0.567 |
coq2 | LOC101732197 | ENSXETP00000025425 | ENSXETP00000019543 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Cytochrome c oxidase subunit Vb, gene 1. | 0.597 |
coq2 | dhdds | ENSXETP00000025425 | ENSXETP00000037669 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Alkyl transferase; Belongs to the UPP synthase family. | 0.901 |
coq2 | fdft1 | ENSXETP00000025425 | ENSXETP00000023788 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Ankyrin repeat and SOCS box containing 1. | 0.707 |
coq2 | ggps1 | ENSXETP00000025425 | ENSXETP00000046271 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Protocadherin 8; Belongs to the FPP/GGPP synthase family. | 0.770 |
coq2 | hmgcs1 | ENSXETP00000025425 | ENSXETP00000037965 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.465 |
coq2 | idi1 | ENSXETP00000025425 | ENSXETP00000007983 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | DNA replication ATP-dependent helicase/nuclease DNA2. | 0.955 |
coq2 | lss | ENSXETP00000025425 | ENSXETP00000043114 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. | 0.732 |
coq2 | mvd | ENSXETP00000025425 | ENSXETP00000046279 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.501 |
coq2 | ndufaf6 | ENSXETP00000025425 | ENSXETP00000005815 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Canopy FGF signaling regulator 2. | 0.703 |
coq2 | ubiad1 | ENSXETP00000025425 | ENSXETP00000010455 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzym [...] | 0.936 |