node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FANCM | REV3L | ENSXETP00000028604 | ENSXETP00000001234 | FA complementation group M. | REV3 like, DNA directed polymerase zeta catalytic subunit. | 0.992 |
FANCM | mad2l2 | ENSXETP00000028604 | ENSXETP00000042109 | FA complementation group M. | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit rev3l and the inserter polymerase rev1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] | 0.752 |
FANCM | pcna | ENSXETP00000028604 | ENSXETP00000010344 | FA complementation group M. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.992 |
FANCM | poli | ENSXETP00000028604 | ENSXETP00000035848 | FA complementation group M. | Neuronal guanine nucleotide exchange factor. | 0.667 |
FANCM | rad52 | ENSXETP00000028604 | ENSXETP00000050577 | FA complementation group M. | Phospholipase D2. | 0.998 |
FANCM | rev1 | ENSXETP00000028604 | ENSXETP00000044231 | FA complementation group M. | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. | 0.780 |
FANCM | ube2v2 | ENSXETP00000028604 | ENSXETP00000014306 | FA complementation group M. | CCR4-NOT transcription complex subunit 7. | 0.643 |
REV3L | FANCM | ENSXETP00000001234 | ENSXETP00000028604 | REV3 like, DNA directed polymerase zeta catalytic subunit. | FA complementation group M. | 0.992 |
REV3L | mad2l2 | ENSXETP00000001234 | ENSXETP00000042109 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit rev3l and the inserter polymerase rev1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] | 0.996 |
REV3L | pcna | ENSXETP00000001234 | ENSXETP00000010344 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.917 |
REV3L | pold2 | ENSXETP00000001234 | ENSXETP00000050034 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Uncharacterized protein. | 0.970 |
REV3L | poli | ENSXETP00000001234 | ENSXETP00000035848 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Neuronal guanine nucleotide exchange factor. | 0.954 |
REV3L | prim1 | ENSXETP00000001234 | ENSXETP00000054265 | REV3 like, DNA directed polymerase zeta catalytic subunit. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.870 |
REV3L | rad52 | ENSXETP00000001234 | ENSXETP00000050577 | REV3 like, DNA directed polymerase zeta catalytic subunit. | Phospholipase D2. | 0.899 |
REV3L | rev1 | ENSXETP00000001234 | ENSXETP00000044231 | REV3 like, DNA directed polymerase zeta catalytic subunit. | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. | 0.986 |
REV3L | ube2n | ENSXETP00000001234 | ENSXETP00000038456 | REV3 like, DNA directed polymerase zeta catalytic subunit. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.885 |
REV3L | ube2v2 | ENSXETP00000001234 | ENSXETP00000014306 | REV3 like, DNA directed polymerase zeta catalytic subunit. | CCR4-NOT transcription complex subunit 7. | 0.903 |
mad2l2 | FANCM | ENSXETP00000042109 | ENSXETP00000028604 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit rev3l and the inserter polymerase rev1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] | FA complementation group M. | 0.752 |
mad2l2 | REV3L | ENSXETP00000042109 | ENSXETP00000001234 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit rev3l and the inserter polymerase rev1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] | REV3 like, DNA directed polymerase zeta catalytic subunit. | 0.996 |
mad2l2 | pcna | ENSXETP00000042109 | ENSXETP00000010344 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit rev3l and the inserter polymerase rev1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.625 |