STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hectd3Zinc finger protein 503. (848 aa)    
Predicted Functional Partners:
pan3
PAN2-PAN3 deadenylation complex subunit pan3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]
   
 
  0.738
pan2-3
Novel protein containing P21-Rho-binding domain.
    
 0.704
fau
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 
 0.626
rps27a
Ribosomal protein S27a.
   
 
 0.547
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 
 0.518
TRRAP
Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.
   
 
 0.506
kiaa2013
Uncharacterized protein KIAA2013 homolog.
      
 0.472
PGM2L1
Phosphoglucomutase 2 like 1.
   
    0.463
pgm2
Actinin alpha 3 (gene/pseudogene).
   
    0.463
ZFAND4
Zinc finger AN1-type containing 4.
   
 
 0.441
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.