STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hspb1Zinc finger MYM-type containing 4; Belongs to the small heat shock protein (HSP20) family. (211 aa)    
Predicted Functional Partners:
mapkapk2
F-box and WD repeat domain containing 5; Belongs to the protein kinase superfamily.
   
 0.991
mapkapk3
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 0.970
cryab
Mitochondrial ribosomal protein L23; Belongs to the small heat shock protein (HSP20) family.
   
 
0.775
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.770
DAXX
Death domain associated protein.
    
 
 0.742
hspa4
Uncharacterized protein.
   
 
 0.718
mapkapk5
Protein kinase domain-containing protein.
    
 
 0.692
hspb8
Fibroblast growth factor 12; Belongs to the small heat shock protein (HSP20) family.
   
 
0.691
rbmx2-2
RNA binding motif protein X-linked 2.
   
 
 0.635
plpp4-2
Phospholipid phosphatase 4.
   
 
 0.635
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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