node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FANCM | b2m | ENSXETP00000028604 | ENSXETP00000003644 | FA complementation group M. | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | 0.854 |
FANCM | meiob | ENSXETP00000028604 | ENSXETP00000002638 | FA complementation group M. | Solute carrier family 12 (potassium/chloride transporter), member 4. | 0.999 |
FANCM | rfwd3 | ENSXETP00000028604 | ENSXETP00000027398 | FA complementation group M. | Heat shock 70 kDa protein 14. | 0.587 |
FANCM | rpa1 | ENSXETP00000028604 | ENSXETP00000035502 | FA complementation group M. | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.999 |
FANCM | rpa2 | ENSXETP00000028604 | ENSXETP00000039231 | FA complementation group M. | Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.854 |
FANCM | smarcal1 | ENSXETP00000028604 | ENSXETP00000051738 | FA complementation group M. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity); Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. | 0.738 |
FANCM | wrn | ENSXETP00000028604 | ENSXETP00000036841 | FA complementation group M. | Cell death-inducing p53-target protein 1. | 0.999 |
b2m | FANCM | ENSXETP00000003644 | ENSXETP00000028604 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | FA complementation group M. | 0.854 |
b2m | meiob | ENSXETP00000003644 | ENSXETP00000002638 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Solute carrier family 12 (potassium/chloride transporter), member 4. | 0.701 |
b2m | primpol | ENSXETP00000003644 | ENSXETP00000015533 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Ubiquitin protein ligase E3 component n-recognin 2. | 0.590 |
b2m | rfwd3 | ENSXETP00000003644 | ENSXETP00000027398 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Heat shock 70 kDa protein 14. | 0.583 |
b2m | rpa1 | ENSXETP00000003644 | ENSXETP00000035502 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.937 |
b2m | rpa3 | ENSXETP00000003644 | ENSXETP00000022063 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Solute carrier family 1 member 3. | 0.886 |
b2m | smarcal1 | ENSXETP00000003644 | ENSXETP00000051738 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity); Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. | 0.453 |
b2m | wrn | ENSXETP00000003644 | ENSXETP00000036841 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Cell death-inducing p53-target protein 1. | 0.867 |
hmces | rfwd3 | ENSXETP00000019823 | ENSXETP00000027398 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Heat shock 70 kDa protein 14. | 0.586 |
hmces | smarcal1 | ENSXETP00000019823 | ENSXETP00000051738 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity); Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. | 0.534 |
meiob | FANCM | ENSXETP00000002638 | ENSXETP00000028604 | Solute carrier family 12 (potassium/chloride transporter), member 4. | FA complementation group M. | 0.999 |
meiob | b2m | ENSXETP00000002638 | ENSXETP00000003644 | Solute carrier family 12 (potassium/chloride transporter), member 4. | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | 0.701 |
meiob | rfwd3 | ENSXETP00000002638 | ENSXETP00000027398 | Solute carrier family 12 (potassium/chloride transporter), member 4. | Heat shock 70 kDa protein 14. | 0.736 |