node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDB1 | crbn | ENSXETP00000034669 | ENSXETP00000044533 | Damage specific DNA binding protein 1. | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | 0.976 |
DDB1 | cul4a | ENSXETP00000034669 | ENSXETP00000003700 | Damage specific DNA binding protein 1. | CULLIN_2 domain-containing protein; Belongs to the cullin family. | 0.913 |
DDB1 | cul4b | ENSXETP00000034669 | ENSXETP00000039229 | Damage specific DNA binding protein 1. | DNL-type zinc finger; Belongs to the cullin family. | 0.913 |
DDB1 | dcaf1 | ENSXETP00000034669 | ENSXETP00000030946 | Damage specific DNA binding protein 1. | NADPH oxidase 4. | 0.983 |
DDB1 | dda1 | ENSXETP00000034669 | ENSXETP00000029871 | Damage specific DNA binding protein 1. | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with cul4a and WD repeat proteins (By similarity); Belongs to the DDA1 family. | 0.989 |
DDB1 | det1 | ENSXETP00000034669 | ENSXETP00000051207 | Damage specific DNA binding protein 1. | ALG3, alpha-1,3- mannosyltransferase. | 0.958 |
DDB1 | dtl | ENSXETP00000034669 | ENSXETP00000028254 | Damage specific DNA binding protein 1. | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] | 0.972 |
crbn | DDB1 | ENSXETP00000044533 | ENSXETP00000034669 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | Damage specific DNA binding protein 1. | 0.976 |
crbn | cul4a | ENSXETP00000044533 | ENSXETP00000003700 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | CULLIN_2 domain-containing protein; Belongs to the cullin family. | 0.779 |
crbn | cul4b | ENSXETP00000044533 | ENSXETP00000039229 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | DNL-type zinc finger; Belongs to the cullin family. | 0.894 |
crbn | cystm1 | ENSXETP00000044533 | ENSXETP00000033400 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | Cysteine-rich and transmembrane domain-containing protein 1. | 0.720 |
crbn | dcaf10 | ENSXETP00000044533 | ENSXETP00000001122 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | DDB1- and CUL4-associated factor 10; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF10 family. | 0.746 |
crbn | dcaf17 | ENSXETP00000044533 | ENSXETP00000003963 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | Crystallin beta B1. | 0.540 |
crbn | dda1 | ENSXETP00000044533 | ENSXETP00000029871 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with cul4a and WD repeat proteins (By similarity); Belongs to the DDA1 family. | 0.734 |
crbn | dtl | ENSXETP00000044533 | ENSXETP00000028254 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] | 0.726 |
cul4a | DDB1 | ENSXETP00000003700 | ENSXETP00000034669 | CULLIN_2 domain-containing protein; Belongs to the cullin family. | Damage specific DNA binding protein 1. | 0.913 |
cul4a | crbn | ENSXETP00000003700 | ENSXETP00000044533 | CULLIN_2 domain-containing protein; Belongs to the cullin family. | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. Belongs to the CRBN family. | 0.779 |
cul4a | cul4b | ENSXETP00000003700 | ENSXETP00000039229 | CULLIN_2 domain-containing protein; Belongs to the cullin family. | DNL-type zinc finger; Belongs to the cullin family. | 0.901 |
cul4a | dcaf1 | ENSXETP00000003700 | ENSXETP00000030946 | CULLIN_2 domain-containing protein; Belongs to the cullin family. | NADPH oxidase 4. | 0.869 |
cul4a | dda1 | ENSXETP00000003700 | ENSXETP00000029871 | CULLIN_2 domain-containing protein; Belongs to the cullin family. | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with cul4a and WD repeat proteins (By similarity); Belongs to the DDA1 family. | 0.757 |