STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
otx2Homeobox protein OTX2; May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer gene cer1 by acting synergistically with siamois and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to stimulate expression (By similarity) (289 aa)    
Predicted Functional Partners:
six3
SIX homeobox 3
   
 
 0.893
fgf8
Fibroblast growth factor 8 (androgen-induced); Belongs to the heparin-binding growth factors family
   
 
 0.888
isl1
ISL LIM homeobox 1
    
 
 0.854
sox2
Transcription factor Sox-2; Transcriptional activator. Functions as a switch in neuronal development, participating in the differentiation of embryonic neuroectodermal cells into neural tissues by making the ectodermal cells responsive to FGF-neuralizing signals (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity)
   
 
 0.853
six6
Uncharacterized protein; SIX homeobox 6
   
 
 0.811
chrd
Chordin; Belongs to the chordin family
   
 
 0.810
ag1
Anterior gradient protein 1; Probably involved in cement gland formation
      
 0.800
t
T, brachyury homolog
   
 
 0.797
neurod1
Neurogenic differentiation 1
   
  
 0.792
pax2
Uncharacterized protein; Paired box 2
   
 
 0.791
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. (Silurana) tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, Xenopus tropicalis, western clawed frog
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