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fbxo5 protein (Xenopus tropicalis) - STRING interaction network
"fbxo5" - F-box only protein 5 in Xenopus tropicalis
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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fbxo5F-box only protein 5; Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 and fzr1/cdh1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding (By similarity) (391 aa)    
Predicted Functional Partners:
cdc20
Uncharacterized protein; Cell division cycle 20 homolog (511 aa)
     
  0.999
plk1
Serine/threonine-protein kinase PLK1; Plays multiple essential roles during mitosis. Phosphorylates the N-terminal domain of cdc25, which leads to cyclin b-cdc2 activation and mitotic entry. Also required for organization of bipolar spindles, and for exit from mitosis. Phosphorylates tpx2 (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family (600 aa)
     
  0.996
ccna2
Cyclin A2; Belongs to the cyclin family (410 aa)
     
   
  0.995
cdk1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily (297 aa)
     
  0.993
anapc2
Anaphase promoting complex subunit 2; Belongs to the cullin family (820 aa)
       
 
  0.992
aurka
Serine/threonine kinase 6; Aurora kinase A; Belongs to the protein kinase superfamily (415 aa)
     
   
  0.984
fzr1
Fizzy/cell division cycle 20 related 1 (493 aa)
     
  0.982
ccnb1
Ccnb1 protein; Cyclin B1; Belongs to the cyclin family (390 aa)
     
 
  0.981
ccnb1.2
Uncharacterized protein; Cyclin B1; Belongs to the cyclin family (397 aa)
     
 
  0.975
skp1
S-phase kinase-associated protein 1; Belongs to the SKP1 family (163 aa)
     
  0.961
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. (Silurana) tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, Xenopus tropicalis, western clawed frog
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