STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppp1r21TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (781 aa)    
Predicted Functional Partners:
cryzl1
Arginine vasopressin receptor 2 (nephrogenic diabetes insipidus).
    
   0.828
cdk2ap1-2
Cyclin-dependent kinase 2 associated protein 1.
    
   0.806
dtnb
Protein cereblon.
    
   0.806
dtna
ZZ-type domain-containing protein.
    
   0.806
rsph3
Nuclear receptor subfamily 0 group B member 2.
    
   0.806
cdk1
Cell division cycle 2, G1 to S and G2 to M; Belongs to the protein kinase superfamily.
     
  0.750
ube2i
SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family.
     
  0.750
c12orf4
Solute carrier family 4 member 9.
    
 
 0.738
plk1
Serine/threonine-protein kinase PLK1; Plays multiple essential roles during mitosis. Phosphorylates the N-terminal domain of cdc25, which leads to cyclin b-cdc2 activation and mitotic entry. Also required for organization of bipolar spindles, and for exit from mitosis. Phosphorylates tpx2 (By similarity).
     
  0.700
wapl
MAPK regulated corepressor interacting protein 2.
     
  0.700
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.