STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (483 aa)    
Predicted Functional Partners:
twf1
Twinfilin-1; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity).
    
 
 0.833
PFN4
Profilin; Belongs to the profilin family.
   
 
 0.784
dbn1
ADF-H domain-containing protein.
   
 
 0.777
dbnl
Adaptor related protein complex 2 subunit sigma 1.
   
 
 0.777
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2.
    
 
 0.728
phlpp1
Cadherin 15.
    
 
 0.728
GRXCR1
Glutaredoxin and cysteine rich domain containing 1.
    
   0.711
wdr1
WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin (By similarity); Belongs to the WD repeat AIP1 family.
   
 
 0.701
cfl1
Cofilin-1; May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Required for formation of the cleavage furrow during cytokinesis.
   
 
 0.676
dstn
Solute carrier family 1 member 2; Belongs to the actin-binding proteins ADF family.
   
 
 0.676
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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