STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC100498450Keratin 61. (270 aa)    
Predicted Functional Partners:
FGA
Fibrinogen alpha chain.
   
 
  0.704
pcsk4
Corticotropin releasing hormone receptor 1, gene 2; Belongs to the peptidase S8 family.
   
  0.507
LOC100490503
Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
   
  0.507
csf1
Nucleophosmin/nucleoplasmin 3.
   
 
  0.506
gstk1
Glutathione S-transferase kappa.
     
 0.505
hook1
Calponin-homology (CH) domain-containing protein.
   
  0.505
ppp2r5c
Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit.
    
  0.504
hmgxb3
HMG box domain-containing protein.
     
  0.499
wnt11-2
Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N- terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not requ [...]
     
  0.499
dvl2
Segment polarity protein dishevelled homolog DVL-2; Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta- catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin- related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along [...]
     
  0.499
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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