STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TTC21BTetratricopeptide repeat domain 21B. (1334 aa)    
Predicted Functional Partners:
ift122
Intraflagellar transport protein 122 homolog; Required for cilia formation during embryonal development. Acts as a negative regulator of Shh signaling.
   
 0.984
ift43
Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.
    
 0.983
WDR35
WD repeat-containing protein 35.
   
 0.981
ift140
Uncharacterized protein.
   
 
 0.944
wdr19
Uncharacterized protein.
   
 
 0.857
wdr19-2
Cyclin-dependent kinase 8.
   
 
 0.857
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 
 0.837
ift57
Intraflagellar transport protein 57 homolog; Required for the formation of cilia. May also have pro- apoptotic function (By similarity); Belongs to the IFT57 family.
  
  
 0.789
ift20
Intraflagellar transport protein 20 homolog; Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.
    
 0.755
ift74
Intraflagellar transport 74 homolog.
   
 0.695
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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