STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH3Notch receptor 3. (2413 aa)    
Predicted Functional Partners:
jag1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.975
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.971
dlc
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.955
dll1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.955
psen2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.934
rbpj
Ubiquinol-cytochrome c reductase core protein 2.
    
 
 0.927
lfng
Beta-1,3-N-acetylglucosaminyltransferase.
    
 0.924
dtx1
Rhomboid domain containing 2.
    
 0.922
psen1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.922
dtx2
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.
    
 0.922
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.