STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
washc5WASH complex subunit 5; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. (1159 aa)    
Predicted Functional Partners:
washc1
WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family.
   
 0.977
washc4
Matrix metallopeptidase 24.
  
 
 0.930
washc3
DEAH-box helicase 33.
    
 
 0.886
aldh18a1
Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
      
 0.752
ing5-2
Inhibitor of growth family member 5.
   
 
 0.731
washc2a
CAP-ZIP_m domain-containing protein.
   
 
 0.731
RCSD1
RCSD domain containing 1.
   
 
 0.610
vps35
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.
    
 
 0.590
reep1
Receptor expression-enhancing protein.
      
 0.587
lars1
MGC97760 protein; Belongs to the class-I aminoacyl-tRNA synthetase family.
      
 0.571
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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