node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GSTZ1 | fsd2 | ENSXETP00000013472 | ENSXETP00000054221 | Glutathione S-transferase zeta 1; Belongs to the GST superfamily. | DEAD-box helicase 18. | 0.520 |
adss | afg1l | ENSXETP00000049199 | ENSXETP00000012648 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Limb and CNS-expressed 1-like. | 0.540 |
adss | cep85l | ENSXETP00000049199 | ENSXETP00000027376 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Calcium/calmodulin dependent protein kinase ID. | 0.540 |
adss | cops3 | ENSXETP00000049199 | ENSXETP00000006828 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.800 |
adss | cops5 | ENSXETP00000049199 | ENSXETP00000012979 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex; Belon [...] | 0.546 |
adss | cops6 | ENSXETP00000049199 | ENSXETP00000050248 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.546 |
adss | cops8 | ENSXETP00000049199 | ENSXETP00000052871 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.540 |
adss | cops9 | ENSXETP00000049199 | ENSXETP00000029333 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | COP9 signalosome complex subunit 9; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation. | 0.540 |
adss | fsd2 | ENSXETP00000049199 | ENSXETP00000054221 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | DEAD-box helicase 18. | 0.547 |
adss | grb2 | ENSXETP00000049199 | ENSXETP00000047276 | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation. | 0.540 |
afg1l | adss | ENSXETP00000012648 | ENSXETP00000049199 | Limb and CNS-expressed 1-like. | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | 0.540 |
afg1l | cep85l | ENSXETP00000012648 | ENSXETP00000027376 | Limb and CNS-expressed 1-like. | Calcium/calmodulin dependent protein kinase ID. | 0.540 |
afg1l | cops3 | ENSXETP00000012648 | ENSXETP00000006828 | Limb and CNS-expressed 1-like. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.540 |
afg1l | cops5 | ENSXETP00000012648 | ENSXETP00000012979 | Limb and CNS-expressed 1-like. | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex; Belon [...] | 0.540 |
afg1l | cops6 | ENSXETP00000012648 | ENSXETP00000050248 | Limb and CNS-expressed 1-like. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.540 |
afg1l | cops8 | ENSXETP00000012648 | ENSXETP00000052871 | Limb and CNS-expressed 1-like. | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.540 |
afg1l | cops9 | ENSXETP00000012648 | ENSXETP00000029333 | Limb and CNS-expressed 1-like. | COP9 signalosome complex subunit 9; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation. | 0.540 |
afg1l | fsd2 | ENSXETP00000012648 | ENSXETP00000054221 | Limb and CNS-expressed 1-like. | DEAD-box helicase 18. | 0.540 |
afg1l | grb2 | ENSXETP00000012648 | ENSXETP00000047276 | Limb and CNS-expressed 1-like. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation. | 0.540 |
cep85l | adss | ENSXETP00000027376 | ENSXETP00000049199 | Calcium/calmodulin dependent protein kinase ID. | Adenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | 0.540 |