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mcm2 protein (Xenopus tropicalis) - STRING interaction network
"mcm2" - DNA replication licensing factor mcm2 in Xenopus tropicalis
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mcm2DNA replication licensing factor mcm2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (884 aa)    
Predicted Functional Partners:
zmcm3
Zygotic DNA replication licensing factor mcm3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute diff [...] (811 aa)
     
0.999
mcm4
DNA replication licensing factor mcm4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (865 aa)
   
0.999
mcm7
DNA helicase; Minichromosome maintenance complex component 7 (716 aa)
     
0.999
mcm5
DNA replication licensing factor mcm5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (735 aa)
     
0.999
cdc45
Cell division cycle 45 homolog (S. cerevisiae) (569 aa)
     
  0.999
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated (557 aa)
   
  0.999
mcm10
Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity) (845 aa)
     
  0.999
cdk2
Uncharacterized protein; Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily (339 aa)
     
  0.999
orc1
Uncharacterized protein; Origin recognition complex, subunit 1 (888 aa)
   
  0.999
pola2
DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (597 aa)
     
  0.999
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. (Silurana) tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, Xenopus tropicalis, western clawed frog
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