node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | SYNW0773 | SYNW0226 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.986 |
hisA | hisC | SYNW0773 | SYNW2318 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Aminotransferases class-I; Conserved hypothetical assignment. | 0.825 |
hisA | hisC/cobC | SYNW0773 | SYNW2334 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Aminotransferases class-I; Citation: Crouzet et al. (1990) J. Bacteriol. 172:5968-5979. | 0.777 |
hisA | hisD | SYNW0773 | SYNW0610 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.986 |
hisA | hisF | SYNW0773 | SYNW1675 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.976 |
hisA | hisF2 | SYNW0773 | SYNW0436 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Putative cyclase hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.979 |
hisA | hisG | SYNW0773 | SYNW1542 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Possible ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.980 |
hisA | hisH | SYNW0773 | SYNW0435 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Putative glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.993 |
hisA | hisH-2 | SYNW0773 | SYNW0723 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Glutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.994 |
hisA | hisIE | SYNW0773 | SYNW1505 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidine biosynthesis bifunctional protein HisIE; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisB | hisA | SYNW0226 | SYNW0773 | Imidazoleglycerol-phosphate dehydratase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.986 |
hisB | hisC | SYNW0226 | SYNW2318 | Imidazoleglycerol-phosphate dehydratase. | Aminotransferases class-I; Conserved hypothetical assignment. | 0.997 |
hisB | hisC/cobC | SYNW0226 | SYNW2334 | Imidazoleglycerol-phosphate dehydratase. | Aminotransferases class-I; Citation: Crouzet et al. (1990) J. Bacteriol. 172:5968-5979. | 0.891 |
hisB | hisD | SYNW0226 | SYNW0610 | Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisB | hisF | SYNW0226 | SYNW1675 | Imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.992 |
hisB | hisF2 | SYNW0226 | SYNW0436 | Imidazoleglycerol-phosphate dehydratase. | Putative cyclase hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.992 |
hisB | hisG | SYNW0226 | SYNW1542 | Imidazoleglycerol-phosphate dehydratase. | Possible ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.982 |
hisB | hisH | SYNW0226 | SYNW0435 | Imidazoleglycerol-phosphate dehydratase. | Putative glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.994 |
hisB | hisH-2 | SYNW0226 | SYNW0723 | Imidazoleglycerol-phosphate dehydratase. | Glutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.994 |
hisB | hisIE | SYNW0226 | SYNW1505 | Imidazoleglycerol-phosphate dehydratase. | Histidine biosynthesis bifunctional protein HisIE; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |