STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SYNW1869Conserved hypothetical protein; Belongs to the UPF0284 family. (394 aa)    
Predicted Functional Partners:
topA
Prokaryotic DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...]
       0.850
SYNW1870
Conserved hypothetical protein; Predicted membrane protein.
 
     0.838
SYNW1868
Conserved hypothetical protein.
       0.799
cbiG/cobJ
Bifunctional cbiH protien and PRECORRIN-3B C17-METHYLTRANSFERASE; Citation: Debussche et al. (1993) J. Bacteriol. 175:7430-7440; Roth et al. (1993) J. Bacteriol. 175:3303-3316.
  
  
 0.786
SYNW1871
Conserved hypothetical protein.
       0.773
CobS
Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
  
 
 0.755
cbiD
Cobalamin biosynthesis protein D; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.680
hisC/cobC
Aminotransferases class-I; Citation: Crouzet et al. (1990) J. Bacteriol. 172:5968-5979.
 
  
 0.670
cobU/cobP
Putative cobinamide kinase; Citation: O' Toole and Excalante-Semerena (1995) J. Biol. Chem. 270:23560-23569; Thomas et al. (2000) J. Biol. Chem. 2275:27576-27586.
  
  
 0.650
cobL
Putative precorrin-6y methylase; Citation: Blanche et al. (1992) J. Bacteriol. 174:1050-1052.
  
  
 0.640
Your Current Organism:
Synechococcus sp. WH 8102
NCBI taxonomy Id: 84588
Other names: S. sp. WH 8102, Synechococcus sp. WH8102
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