STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (802 aa)    
Predicted Functional Partners:
HRG
Histidine-rich glycoprotein.
   
 0.972
SERPINF2
Alpha-2-antiplasmin; Belongs to the serpin family.
   
 0.959
FGA
Fibrinogen alpha chain.
   
 0.953
FGB
Fibrinogen beta chain.
   
 0.943
SERPINC1
Antithrombin-III; Belongs to the serpin family.
   
 0.933
SERPIND1
Heparin cofactor 2 isoform A; Belongs to the serpin family.
   
 0.923
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
  
  
0.886
APOB
Apolipoprotein B-100.
   
 0.886
AMBP
Protein AMBP.
   
 0.813
S100A10
Protein S100-A10; Belongs to the S-100 family.
    
 0.796
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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