STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYP2C18Cytochrome P450 2C18; Belongs to the cytochrome P450 family. (393 aa)    
Predicted Functional Partners:
TBXAS1
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
 0.555
Y1Q_0003462
Uncharacterized protein.
  
 0.533
Y1Q_0008984
Cytochrome P450 11B, mitochondrial-like; Belongs to the cytochrome P450 family.
  
 
 0.533
Y1Q_0003460
Uncharacterized protein.
  
 0.523
Y1Q_0017342
Cytochrome P450 4F22-like.
  
 0.520
CYP19A1
Aromatase; Belongs to the cytochrome P450 family.
  
 
 0.510
AASDH
Acyl-CoA synthetase family member 4 isoform A.
  
 0.505
WRN
Werner syndrome ATP-dependent helicase.
    
 0.496
CYP7A1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
  
  
 0.493
CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
 
 0.479
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.