STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa)    
Predicted Functional Partners:
CCNA2
Cyclin-A2; Belongs to the cyclin family.
   
 0.964
CCNE1
G1/S-specific cyclin-E1; Belongs to the cyclin family.
   
 0.951
CCNA1-1
Cyclin-A1 isoform C; Belongs to the cyclin family.
   
 0.941
CCNE2-1
G1/S-specific cyclin-E2 isoform B; Belongs to the cyclin family.
   
 0.936
SKP2
S-phase kinase-associated protein 2.
   
 0.898
ITM2B
Integral membrane protein 2B isoform B.
   
 0.872
CDC6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.867
CCND1
G1/S-specific cyclin-D1; Belongs to the cyclin family.
   
 0.865
CDK1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
  
0.825
CCNB2
G2/mitotic-specific cyclin-B2; Belongs to the cyclin family.
   
 0.806
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.