STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEF16630.1PFAM: DNA ligase, ATP-dependent, central; KEGG: ttm:Tthe_0704 ATP dependent DNA ligase. (307 aa)    
Predicted Functional Partners:
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.976
AEF16066.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.963
AEF16653.1
KEGG: ttm:Tthe_0720 PHP domain protein; PFAM: PHP, C-terminal; SMART: DNA-directed DNA polymerase X; Helix-hairpin-helix DNA-binding motif, class 1; Polymerase/histidinol phosphatase, N-terminal.
  
 0.929
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.917
AEF17007.1
KEGG: tit:Thit_1351 hypothetical protein.
  
 0.826
AEF17006.1
KEGG: ccb:Clocel_3596 helicase domain-containing protein; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal.
 
 
 0.607
AEF16090.1
KEGG: ttm:Tthe_0026 signal peptidase I; TIGRFAM: Peptidase S26A, signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region.
    
 0.604
AEF16629.1
KEGG: ttm:Tthe_0703 peptidoglycan glycosyltransferase; PFAM: Penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain.
       0.581
AEF17294.1
SMC domain protein; PFAM: RecF/RecN/SMC; Rad50 zinc hook; KEGG: ttm:Tthe_1385 SMC domain protein.
   
 0.551
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.505
Your Current Organism:
Thermoanaerobacterium xylanolyticum
NCBI taxonomy Id: 858215
Other names: T. xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum DSM 7097, Thermoanaerobacterium xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum str. LX-11, Thermoanaerobacterium xylanolyticum strain LX-11
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