Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (336 aa)
Predicted Functional Partners:
Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA) (273 aa)
Fumarate reductase flavoprotein subunit (714 aa)
Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (267 aa)
Hypothetical protein (183 aa)
Hypothetical protein (168 aa)
Prenyltransferase (294 aa)
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (242 aa)
D-amino acid dehydrogenase (dadA); Catalyzes the oxidative deamination of D-amino acids. Has broad substrate specificity; is mostly active on D-proline, and to a lesser extent, on several other D-amino acids such as D- alanine, D-phenylalanine and D-serine. Mediates electron transport from D-proline to coenzyme Q1 in vitro, and is involved in the electron transport chain from D-proline to the c-type cytochrome in vivo (410 aa)
Aspartate alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (117 aa)