node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HP_0558 | nixA | HP_0558 | HP_1077 | Beta ketoacyl-acyl carrier protein synthase II (fabF); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | 0.714 |
HP_1078 | HP_1079 | HP_1078 | HP_1079 | Predicted coding region HP1078; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP1079; Has nucleotide phosphatase activity toward ATP and GTP, but not toward CTP, TTP and ADP. | 0.735 |
HP_1078 | nixA | HP_1078 | HP_1077 | Predicted coding region HP1078; Hypothetical protein; identified by GeneMark; putative. | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | 0.601 |
HP_1079 | HP_1078 | HP_1079 | HP_1078 | Predicted coding region HP1079; Has nucleotide phosphatase activity toward ATP and GTP, but not toward CTP, TTP and ADP. | Predicted coding region HP1078; Hypothetical protein; identified by GeneMark; putative. | 0.735 |
HP_1079 | nixA | HP_1079 | HP_1077 | Predicted coding region HP1079; Has nucleotide phosphatase activity toward ATP and GTP, but not toward CTP, TTP and ADP. | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | 0.537 |
HP_1338 | hypB | HP_1338 | HP_0900 | Conserved hypothetical protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | 0.460 |
HP_1338 | nixA | HP_1338 | HP_1077 | Conserved hypothetical protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | 0.574 |
HP_1338 | ureA | HP_1338 | HP_0073 | Conserved hypothetical protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. | Urease alpha subunit (ureA) (urea amidohydrolase); Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; In the N-terminal section; belongs to the urease gamma subunit family. | 0.505 |
hypB | HP_1338 | HP_0900 | HP_1338 | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Conserved hypothetical protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. | 0.460 |
hypB | nixA | HP_0900 | HP_1077 | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | 0.471 |
hypB | ureA | HP_0900 | HP_0073 | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Urease alpha subunit (ureA) (urea amidohydrolase); Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; In the N-terminal section; belongs to the urease gamma subunit family. | 0.946 |
hypB | ureB | HP_0900 | HP_0072 | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Urease beta subunit (urea amidohydrolase) (ureB); Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. | 0.760 |
hypB | ureE | HP_0900 | HP_0070 | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Urease accessory protein (ureE); Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. | 0.964 |
hypB | ureF | HP_0900 | HP_0069 | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Urease accessory protein (ureF); Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. | 0.926 |
hypB | ureI | HP_0900 | HP_0071 | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Urease accessory protein (ureI); Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below. | 0.483 |
nixA | HP_0558 | HP_1077 | HP_0558 | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | Beta ketoacyl-acyl carrier protein synthase II (fabF); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 0.714 |
nixA | HP_1078 | HP_1077 | HP_1078 | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | Predicted coding region HP1078; Hypothetical protein; identified by GeneMark; putative. | 0.601 |
nixA | HP_1079 | HP_1077 | HP_1079 | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | Predicted coding region HP1079; Has nucleotide phosphatase activity toward ATP and GTP, but not toward CTP, TTP and ADP. | 0.537 |
nixA | HP_1338 | HP_1077 | HP_1338 | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | Conserved hypothetical protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. | 0.574 |
nixA | hypB | HP_1077 | HP_0900 | Nickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. | Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | 0.471 |