STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nixANickel transport protein (nixA); High-affinity nickel intake protein. Imports nickel ions in an energy-dependent fashion. Necessary for the expression of catalytically active urease; Belongs to the NiCoT transporter (TC 2.A.52) family. (331 aa)    
Predicted Functional Partners:
HP_0558
Beta ketoacyl-acyl carrier protein synthase II (fabF); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 
    0.714
ureE
Urease accessory protein (ureE); Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.
  
  
 0.658
ureA
Urease alpha subunit (ureA) (urea amidohydrolase); Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; In the N-terminal section; belongs to the urease gamma subunit family.
  
  
 0.641
HP_1078
Predicted coding region HP1078; Hypothetical protein; identified by GeneMark; putative.
       0.601
ureF
Urease accessory protein (ureF); Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
  
  
 0.592
HP_1338
Conserved hypothetical protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family.
     
 0.574
ureI
Urease accessory protein (ureI); Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below.
      
 0.545
HP_1079
Predicted coding region HP1079; Has nucleotide phosphatase activity toward ATP and GTP, but not toward CTP, TTP and ADP.
       0.537
ureB
Urease beta subunit (urea amidohydrolase) (ureB); Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
  
  
 0.495
hypB
Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for maturation of urease. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.
  
  
 0.471
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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