STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HP_1231DNA polymerase III delta prime subunit (holB); Similar to GB:L01483 SP:P28631 GB:L04577 PID:145783 PID:145799 percent identity: 48.57; identified by sequence similarity; putative. (218 aa)    
Predicted Functional Partners:
HP_1247
Predicted coding region HP1247; Could be the functional equivalent of DNA polymerase III delta subunit (HolA).
   
 0.998
dnaN
DNA polymerase III beta-subunit (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiat [...]
 
 
 0.994
dnaE
DNA polymerase III alpha-subunit (dnaE); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.
  
 0.994
HP_1387
DNA polymerase III epsilon subunit (dnaQ); Similar to GB:K00985 SP:P03007 GB:X04027 PID:1208975 PID:147679 percent identity: 35.05; identified by sequence similarity; putative.
   
 0.989
ssb
Single-strand DNA-binding protein (ssb); Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
    
 
 0.928
rppH
Invasion protein (invA); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily.
  
    0.839
lysC
Aspartokinase (lysC); Similar to GB:M93419 PID:142540 percent identity: 48.01; identified by sequence similarity; putative; Belongs to the aspartokinase family.
  
  
 0.838
HP_1230
Predicted coding region HP1230; Hypothetical protein; identified by GeneMark; putative.
  
    0.837
folP
Dihydropteroate synthase (folP); Bifunctional enzyme that catalyzes the formation of dihydropteroate, the immediate precursor of folic acid and the reduction of dihydropteroate to tetrahydropteroate. In the C-terminal section; belongs to the DHPS family.
  
    0.837
pgbB
Predicted coding region HP0863; Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components.
  
    0.756
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.