STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFS47661.1Hypothetical protein. (242 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.942
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.933
AFS47662.1
Glycine cleavage system T-protein-like,folate-binding protein, aminomethyltransferase-like protein; PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; Belongs to the GcvT family.
 
  
 0.930
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
  
  
 0.916
AFS47694.1
PFAM: Glycine cleavage T-protein C-terminal barrel domain; Domain of unknown function (DUF1989); Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein; Belongs to the GcvT family.
   
 
 0.904
AFS47021.1
PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; TIGRFAM: glycine cleavage system T protein.
   
 
 0.901
AFS47257.1
Pyridoxal phosphate-dependent enzyme; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: cystathionine beta-lyase, bacterial.
  
 
 0.858
AFS47659.1
PFAM: Adenylyl sulfate kinase.
 
  
 0.738
AFS48069.1
PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family.
  
  
 0.702
AFS47221.1
PFAM: Homocysteine S-methyltransferase.
  
  
 0.701
Your Current Organism:
alpha proteobacterium HIMB5
NCBI taxonomy Id: 859653
Other names: a. proteobacterium HIMB5
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